ArticleThe Journal of clinical endocrinology and metabolism2024
Hemoglobin Glycation Index: A Novel Risk Factor for Incident Chronic Kidney Disease in an Apparently Healthy Population.
Article in The Journal of clinical endocrinology and metabolism, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Preoperative hemoglobin glycation index and postoperative complications after non-cardiac surgery: a retrospective cohort study.Anesthesiology and perioperative science · 2026Article
- Association between hemoglobin glycation index and poor prognosis in patients with AKI: a retrospective cohort analysis of the MIMIC-IV database.Renal failure · 2025Article
- Article
- Association of Hemoglobin Glycation Index With All-Cause Mortality, Cardiac Mortality, and Cardiovascular Mortality in the General Population: A Retrospective Cohort Study of NHANES Data.Reviews in cardiovascular medicine · 2025Article
- Relationship between hemoglobin glycation index and Cushing's syndrome: a cross-sectional study in Chinese populations.Frontiers in endocrinology · 2025Article
- Association Between the Hemoglobin Glycation Index (HGI) and Risk of Diabetic Nephropathy: A Retrospective Cohort Study.Diabetes, metabolic syndrome and obesity : targets and therapy · 2025Article
- Association of haemoglobin glycation index with all-cause and cardiovascular disease mortality in diabetic kidney disease: a cohort study.Diabetology & metabolic syndrome · 2024Article
- Risk and mediation analyses of hemoglobin glycation index and survival prognosis in patients with sepsis.Clinical and experimental medicine · 2024Article
- Risk analysis of the association between different hemoglobin glycation index and poor prognosis in critical patients with coronary heart disease-A study based on the MIMIC-IV database.Cardiovascular diabetology · 2024Article
Corrections and comments
- Erratum issued
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
contextChronic kidney disease (CKD) is a worldwide health problem. Recent literature has shown an association of hemoglobin glycation index (HGI) and CKD in patients with dysglycemia.
objectiveThe aim of this study was to reveal the impact of HGI as a predictor for incident CKD in the general population.
methodsCKD was defined as dipstick proteinuria or estimated glomerular rate (eGFR) < 60 mL/min/1.73 m2. Impact of HGI on incident CKD was assessed using the data from CKD-free health examinees (N = 23 467, 4.1% with diabetes) followed for a mean of 5.1 years: Cox proportional hazards model was employed with multivariate adjustment for age, systolic blood pressure, eGFR, fasting plasma glucose, body mass index, log[alanine aminotransferase], log[triglycerides], high-density lipoprotein cholesterol, platelet counts, smoking, and sex. Elevated level of HGI in subjects with CKD was ascertained after propensity score matching of another group of health examinees (N = 2580, 7.6% with diabetes).
resultsIn the former group, CKD developed in 2540 subjects and HGI was the second most robust predictor for CKD, following low eGFR. With adjustment for the 11 covariates, the hazard ratio of HGI (95% CI) for CKD was 1.293 (1.238 to 1.349) (P < .0001). The population attributable risk of HGI for CKD was 4.2%. In the latter group, among 708 subjects matched 1:1 for 9 covariates, HGI was significantly elevated in subjects with CKD (median [interquartile range] -0.208 [-0.504 to -0.156] vs -0.284 [-0.582 to 0.052], P = .03).
conclusionHGI was a novel risk factor for CKD in the general population.
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