Evidence map›Paper›PMID 37930825›Full record

ArticleACS sensors2023

Detection of Pulmonary Fibrosis with a Collagen-Mimetic Peptide.

Isabella M Borgula, Sergey Shuvaev, Eric Abston, Nicholas J Rotile, Jonah Weigand-Whittier, Iris Y Zhou, Peter Caravan, Ronald T Raines

Open access · greenAbstract read
In one paragraph

Article in ACS sensors, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Article
  3. Around the collagen triple helix: an introduction to studying associated genetic and acquired diseases.Matrix biology : journal of the International Society for Matrix Biology · 2025
    Review
  4. Review
  5. Molecular Imaging of Pulmonary Fibrosis.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2025
    Review
  6. Collagen Hybridizing Peptide-Based Radiotracers for Molecular Imaging of Collagen Turnover in Pulmonary Fibrosis.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2025
    Article
  7. Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Isabella M BorgulaDepartment of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States.
Sergey ShuvaevDepartment of Radiology, Massachusetts General Hospital, Boston, Massachusetts 02124, United States.ORCID 0000-0001-7903-0648
Eric AbstonAthinoula A. Martinos Center for Biomedical Imaging, The Institute for Innovation in Imaging, Massachusetts General Hospital and Harvard Medical School, 149 Thirteenth Street, Charlestown, Massachusetts 02129, United States.
Nicholas J RotileAthinoula A. Martinos Center for Biomedical Imaging, The Institute for Innovation in Imaging, Massachusetts General Hospital and Harvard Medical School, 149 Thirteenth Street, Charlestown, Massachusetts 02129, United States.
Jonah Weigand-WhittierAthinoula A. Martinos Center for Biomedical Imaging, The Institute for Innovation in Imaging, Massachusetts General Hospital and Harvard Medical School, 149 Thirteenth Street, Charlestown, Massachusetts 02129, United States.
Iris Y ZhouAthinoula A. Martinos Center for Biomedical Imaging, The Institute for Innovation in Imaging, Massachusetts General Hospital and Harvard Medical School, 149 Thirteenth Street, Charlestown, Massachusetts 02129, United States.ORCID 0000-0002-4351-7398
Peter CaravanDepartment of Radiology, Massachusetts General Hospital, Boston, Massachusetts 02124, United States.ORCID 0000-0002-3179-6537
Ronald T RainesDepartment of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States.ORCID 0000-0001-7164-1719
Massachusetts General Hospital · USMassachusetts Institute of Technology · US

Funding

PET-MR Imaging of pulmonary fibrosisR01HL153606 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI CARAVAN, PETER D, CATANA, CIPRIAN · 2021 to 2025
$4.1M
Protein ChemistryR35GM148220 · NIGMS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI Ronald T Raines · 2023 to 2026
$2.2M
Optimization of PET probe for imaging lung fibrogenesisR33HL154125 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI CARAVAN, PETER D · 2020 to 2021
$1.2M
Chemistry and Biology of CollagenR56AR044276 · NIAMS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI RAINES, RONALD T · 2019 to 2020
$826k
Quantitative MRI-PET Imaging of Pulmonary FibrosisK25HL148837 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI ZHOU, IRIS YUWEN · 2020 to 2023
$686k
Console Upgrade for 4.7T PET-MRI Preclinical ScannerS10OD034258 · OD · MASSACHUSETTS GENERAL HOSPITAL · PI FARRAR, CHRISTIAN T · 2023 to 2023
$600k
MRI-Compatible PET Insert for Small Bore ScannerS10OD023503 · OD · MASSACHUSETTS GENERAL HOSPITAL · PI CARAVAN, PETER D · 2017 to 2017
$600k
Inductively Coupled Plasma Mass SpectrometerS10OD032138 · OD · MASSACHUSETTS GENERAL HOSPITAL · PI CARAVAN, PETER D · 2022 to 2022
$598k
Electronics Upgrade for 11.7 TS10OD025234 · OD · MASSACHUSETTS GENERAL HOSPITAL · PI CARAVAN, PETER D · 2018 to 2018
$595k
Automation Equipment for Human PET Radiotracer ProductionS10OD028499 · OD · MASSACHUSETTS GENERAL HOSPITAL · PI CARAVAN, PETER D · 2021 to 2021
$325k
NHLBI NIH HHS K25 HL148837NHLBI NIH HHS R01 HL153606NHLBI NIH HHS R33 HL154125NIAMS NIH HHS R56 AR044276NIGMS NIH HHS R35 GM148220NIH HHS S10 OD023503NIH HHS S10 OD025234NIH HHS S10 OD028499NIH HHS S10 OD032138NIH HHS S10 OD034258
6 · The paper itself

Abstract

Idiopathic pulmonary fibrosis (IPF) is a disease of unknown etiology that is characterized by excessive deposition and abnormal remodeling of collagen. IPF has a mean survival time of only 2-5 years from diagnosis, creating a need to detect IPF at an earlier stage when treatments might be more effective. We sought to develop a minimally invasive probe that could detect molecular changes in IPF-associated collagen. Here, we describe the design, synthesis, and performance of [

Indexed as

Gallium RadioisotopesIdiopathic Pulmonary FibrosisAnimalsBleomycinCollagenLungMiceBleomycinCollagenGallium Radioisotopesextracellular matrixfluoroprolineidiopathic pulmonary fibrosisimaginglungpositron emission tomographyprobetriple helix

Identifiers

PMID37930825
PMCPMC10842190
OpenAlexW4388425198

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.