ArticleIndian journal of pediatrics2025
Cognitive Function in Early Onset Type 1 Diabetes in Children.
Article in Indian journal of pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Cognitive skills in children and adolescents with type 1 diabetes: a scoping review and meta-analysis.BMJ open diabetes research & care · 2026Pooled it
- Clinical Aspects and Molecular Mechanisms of Cognitive Dysfunction in Children and Adolescents with Type 1 Diabetes.Children (Basel, Switzerland) · 2026Review
- Article
- Neurocognitive Effects of Early Onset Diabetes- Time to Bring Down the Highs and Lows.Indian journal of pediatrics · 2025Article
- The Effectiveness of Unified Protocols for Transdiagnostic Treatment on Detective Thinking and Reflective Functioning of Children with Type 1 Diabetes.International journal of preventive medicine · 2025Article
- Normative Data for External Genitalia Parameters in Female Newborns.Indian journal of pediatrics · 2024Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
objectivesTo assess cognitive function and factors affecting it in Indian children with early-onset type 1 diabetes (T1D) (less than 6 y).
methodsThis cross-sectional, single-centre study recruited children diagnosed with T1D before 6 y of age and having a disease duration of at least 2 y, as cases. Controls were age- and sex-matched apparently healthy children or siblings. Children with birth asphyxia, intellectual disability, syndromic children, or pre-existing psychiatric illness were excluded. Enrolled children underwent cognitive assessment using Malin's Intelligence Scale for Indian Children (MISIC), and scores in various subtests were compared between cases and controls.
resultsA total of 60 children were enrolled in each group. When compared to controls, cases had significantly lower scores on most subtests, verbal, performance and overall Intelligence Quotient (IQ- 100.62 ± 3.26 vs. 103.23 ± 1.22). HbA1c >9%, severe hypoglycemia and lesser duration since the last diabetic ketoacidosis (DKA) episode significantly correlated with lower neurocognitive scores.
conclusionsChildren with early onset T1D showed significant deficits in various cognitive domains and IQ. Poor glycemic control, higher glycemic variability and exposure to severe hypoglycemia are risk factors for poor cognitive outcomes in these children. Further longitudinal studies could potentially aid in a finer understanding of factors affecting cognitive functioning in T1D children in developing countries.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.