Evidence map›Paper›PMID 37930593›Full record

ArticleJournal, genetic engineering & biotechnology2023

Significant role of some miRNAs as biomarkers for the degree of obesity.

Weaam Gouda, Amr E Ahmed, Lamiaa Mageed, Amgad K Hassan, Mie Afify, W I Hamimy, Halla M Ragab, Nabila Abd El Maksoud, Abdou K Allayeh, Mohamed D E Abdelmaksoud

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In one paragraph

Article in Journal, genetic engineering & biotechnology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Weaam GoudaBiochemistry Department, Biotechnology Research Institute, National Research Centre, Giza, Egypt. weaamgoudaali@gmail.com.ORCID http://orcid.org/0000-0002-5571-142X
Amr E AhmedDepartment of Biotechnology and Life Science, Faculty of Postgraduate Studies for Advanced Sciences, Beni-Suef University, Beni-Suef, Egypt.
Lamiaa MageedBiochemistry Department, Biotechnology Research Institute, National Research Centre, Giza, Egypt.
Amgad K HassanBiochemistry Department, Biotechnology Research Institute, National Research Centre, Giza, Egypt.
Mie AfifyBiochemistry Department, Biotechnology Research Institute, National Research Centre, Giza, Egypt.
W I HamimyAnesthesia Department, Obesity, Surgery Unit, Faculty of Medicine, Cairo University, Giza, Egypt.
Halla M RagabBiochemistry Department, Biotechnology Research Institute, National Research Centre, Giza, Egypt.
Nabila Abd El MaksoudBiochemistry Department, Biotechnology Research Institute, National Research Centre, Giza, Egypt.
Abdou K AllayehEnvironment and Climate Change Institute, National Research Centre, Giza, Egypt.
Mohamed D E AbdelmaksoudBiochemistry Department, Biotechnology Research Institute, National Research Centre, Giza, Egypt.
National Research Centre · EGBeni-Suef University · EGCairo University · EG

Funding

National Research Centre 12060170
6 · The paper itself

Abstract

backgroundObesity is one of the most serious problems over the world. MicroRNAs have developed as main mediators of metabolic processes, playing significant roles in physiological processes. Thus, the present study aimed to evaluate the expressions of (miR-15a, miR-Let7, miR-344, and miR-365) and its relationship with the different classes in obese patients.

methodsA total of 125 individuals were enrolled in the study and classified into four groups: healthy non-obese controls (n = 50), obese class I (n = 24), obese class II (n = 17), and obese class III (n = 34) concerning body mass index (BMI < 30 kg/m

resultsThere was a significant difference between different obese classes and controls (P < 0.05) concerning (BMI, TC, TG, HDL, and LDL). In contrast, fasting glucose, kidney, and liver functions had no significant difference. Our data revealed that the expression of miR-15a and miR-365 were significantly associated with different obese classes. But the circulating miR-Let7 and miR-344 were not significantly related to obesity in different classes.

conclusionOur study indicated that miR-15a and miR-365 might consider as biomarkers for the obesity development into different obese classes. Thus, the relationship between regulatory microRNAs and disease has been the object of intense investigation.

Indexed as

Body mass index (BMI)MicroRNAsObesityObesity classesQuantitative real-time PCR (RT-qPCR)

Identifiers

PMID37930593
PMCPMC10628096
OpenAlexW4388414550

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.