Evidence map›Paper›PMID 37930490›Full record

ArticleSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2023

Associations of serum cortisol and inflammatory marker features with depression and anxiety in young women with gynecologic cancer.

Ning Qin, Shuijing Yi, Chanyuan Dai, Xiangyu Liu, Yinglong Duan, Yi Zhou, Ziyu Wan, Yue Kang, Xing Zhou, Jianfei Xie and 1 more

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Article in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.2field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 5 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Ning QinNursing Department, The Third Xiangya Hospital, Central South University, Changsha, Hunan, China.
Shuijing YiDepartment of Gynecology, The Third Xiangya Hospital, Central South University, Changsha, Hunan, China.
Chanyuan DaiDepartment of Gynecology, The Third Xiangya Hospital, Central South University, Changsha, Hunan, China.
Xiangyu LiuHunan Cancer Hospital, Changsha, Hunan, China.
Yinglong DuanNursing Department, The Third Xiangya Hospital, Central South University, Changsha, Hunan, China.
Yi ZhouXiangya Nursing School, Central South University, Changsha, Hunan, China.
Ziyu WanXiangya Nursing School, Central South University, Changsha, Hunan, China.
Yue KangXiangya Nursing School, Central South University, Changsha, Hunan, China.
Xing ZhouXiangya Nursing School, Central South University, Changsha, Hunan, China.
Jianfei XieNursing Department, The Third Xiangya Hospital, Central South University, Changsha, Hunan, China. xiejianfei@csu.edu.cn.
Andy S K ChengDepartment of Rehabilitation Sciences, The Hong Kong Polytechnic University, Hong Kong, China.
Central South University · CNHong Kong Polytechnic University · HKHunan Cancer Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeSerum cortisol and inflammatory markers may play a role in depression and anxiety, but little is known about whether various features of serum cortisol and inflammatory markers have different associations with depression and anxiety. This study examines the associations of serum cortisol and inflammatory marker features with depression and anxiety in young women with gynecologic cancer.

methodsSixty-four young women with gynecologic cancer, aged 15-39 years, were recruited in a tertiary general hospital and a tertiary hospital specializing in oncology in China from May to December 2021. The Hospital Anxiety and Depression Scale was used to evaluate depression and anxiety. Blood samples were taken at 8 am, 4 pm, and 10 pm on the same day to examine the various features (average, variability, and diurnal patterns) of serum cortisol and inflammatory markers, namely C-reactive protein (CRP), interleukin-6 (IL-6), and tumor necrosis factor alpha (TNF-α).

resultsYoung women with gynecologic cancer who reported depression/anxiety had significantly higher average levels of serum cortisol, IL-6 and TNF-α than those who did not. The dysregulations in the diurnal patterns of serum cortisol and IL-6 were associated with depression and anxiety. Serum cortisol levels were significantly higher in the depression/anxiety group at 10 pm. Depression and anxiety were associated with elevated levels of IL-6 and TNF-α at each time point.

conclusionThis study revealed various associations of serum cortisol and inflammatory marker features with depression and anxiety in young women with gynecologic cancer. Further research is needed to understand the role of serum cortisol and inflammatory marker features in the progression of depression and anxiety.

Indexed as

Genital Neoplasms, FemaleHydrocortisoneAnxietyDepressionFemaleHumansInterleukin-6Tumor Necrosis Factor-alphaHydrocortisoneInterleukin-6Tumor Necrosis Factor-alphaAnxietyCircadian rhythmDepressionGlucocorticoidGynecologic neoplasms

Identifiers

PMID37930490
OpenAlexW4388417539

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.