Maternal Diabetes and Cardiovascular Health in the Offspring.

Riasoya Jodah, Alisa Arunamata, Alaina K Kipps, Sharon Chen, Katie Jo Stauffer, Elif Seda Selamet Tierney

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Article in Pediatric cardiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

6 authors.

Riasoya JodahStanford University School of Medicine, Palo Alto, CA, USA.

Alisa ArunamataDivision of Pediatric Cardiology, Department of Pediatrics, Stanford Children's Health (Lucile Packard Children's Hospital), Palo Alto, CA, USA.

Alaina K KippsDivision of Pediatric Cardiology, Department of Pediatrics, Stanford Children's Health (Lucile Packard Children's Hospital), Palo Alto, CA, USA.

Sharon ChenDivision of Pediatric Cardiology, Department of Pediatrics, Stanford Children's Health (Lucile Packard Children's Hospital), Palo Alto, CA, USA.

Katie Jo StaufferDivision of Pediatric Cardiology, Department of Pediatrics, Stanford Children's Health (Lucile Packard Children's Hospital), Palo Alto, CA, USA.

Elif Seda Selamet TierneyDivision of Pediatric Cardiology, Department of Pediatrics, Stanford Children's Health (Lucile Packard Children's Hospital), Palo Alto, CA, USA. tierneys@stanford.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pulse wave velocity (PWV) has been explored to predict cardiovascular health in adults. Less is known about neonatal PWV. We evaluated the association between arterial stiffness of neonates of mothers (NoM) with diabetes and childhood health. Neonatal brachial-femoral PWV (bfPWV) was measured after birth and neonates followed for a median of 5.2 years [1 month-6.6 years]. 36 pregnant women with pregestational diabetes mellitus PGDM (n = 12), gestational diabetes mellitus (GDM) (n = 13), and controls (n = 11) were enrolled. Neonates were similar in weight, gestational age, and delivery mode. 26 neonates had follow-up data including weight, height and blood pressure. More mothers with PGDM had poor glycemic control compared to mothers with GDM (83% vs. 8%; p = 0.0002). PWV was higher in NoM with PGDM than controls (3.4 ± 0.5 vs. 2.6 ± 0.8 m/s; p = 0.04). At follow-up, children of mothers with diabetes (n = 16) had higher weight percentile (78.5 ± 27.9 vs 49.5 ± 34.6%; p = 0.02) and diastolic blood pressure (DBP) (68 ± 13.6 vs 57.3 ± 4.3 mmHg; p = 0.01) than controls (n = 10). No correlation emerged between neonatal PWV and childhood body mass index (BMI) or maternal HbA1c. Results suggest maternal diabetes affect neonatal arterial stiffness and childhood blood pressure; however, the mechanism is unclear. The long-term implications of these findings warrant further investigation.

Indexed as

Cardiovascular DiseasesDiabetes, GestationalPregnancy in DiabeticsPrenatal Exposure Delayed EffectsVascular StiffnessAdultBlood PressureCase-Control StudiesChildChild, PreschoolFemaleFollow-Up StudiesHumansInfantInfant, NewbornMaleArterial stiffnessDiabetes mellitusOffspringPulse wave velocity

Identifiers

PMID37930377

DOI10.1007/s00246-023-03333-4

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.