Evidence map›Paper›PMID 37930375›Full record

ArticleAnalytical and bioanalytical chemistry2024

Transistor-based immunosensor using AuNPs-Ab2-HRP enzyme nanoprobe for the detection of antigen biomarker in human blood.

Rong Zou, Lei Cao, Nan Wu, Gang Chang, Li Li, Lu Xiao, Huiling Yan, Hongjie Li, Ping Wang, Ting Bao and 4 more

Abstract read
PubMed Publisher
In one paragraph

Article in Analytical and bioanalytical chemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 1 institution in 1 country.

Rong Zou *State Key Laboratory of Biocatalysis and Enzyme Engineering, School of Life Sciences, Hubei University, Wuhan, 430062, Hubei, China.
Lei Cao *State Key Laboratory of Biocatalysis and Enzyme Engineering, School of Life Sciences, Hubei University, Wuhan, 430062, Hubei, China.
Nan WuCollege of Chemistry and Chemical Engineering, Hubei University, Wuhan, 430062, Hubei, China.
Gang ChangMinistry of Education Key Laboratory for the Green Preparation and Application of Functional Materials, College of Materials Science and Engineering, Hubei University, Wuhan, 430062, China.
Li LiCollege of Chemistry and Chemical Engineering, Hubei University, Wuhan, 430062, Hubei, China.
Lu XiaoCollege of Chemistry and Chemical Engineering, Hubei University, Wuhan, 430062, Hubei, China.
Huiling YanCollege of Chemistry and Chemical Engineering, Hubei University, Wuhan, 430062, Hubei, China.
Hongjie LiCollege of Chemistry and Chemical Engineering, Hubei University, Wuhan, 430062, Hubei, China.
Ping WangDepartment of Clinical Laboratory, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430000, Hubei, China. Wping7722@sina.com.cn.
Ting BaoCollege of Chemistry and Chemical Engineering, Hubei University, Wuhan, 430062, Hubei, China.
Xiuhua ZhangCollege of Chemistry and Chemical Engineering, Hubei University, Wuhan, 430062, Hubei, China.
Shengfu WangCollege of Chemistry and Chemical Engineering, Hubei University, Wuhan, 430062, Hubei, China.
Yaping WangState Key Laboratory of Biocatalysis and Enzyme Engineering, School of Life Sciences, Hubei University, Wuhan, 430062, Hubei, China. 20110028@hubu.edu.cn.
Hanping HeState Key Laboratory of Biocatalysis and Enzyme Engineering, School of Life Sciences, Hubei University, Wuhan, 430062, Hubei, China. hehanping@hubu.edu.cn.
Hubei University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Alpha-fetoprotein (AFP) is inextricably linked to various diseases, including liver cancer. Thus, detecting the content of AFP in biology has great significance in diagnosis, treatment, and intervention. Motivated by the urgent need for affordable and convenient electronic sensors in the analysis and detection of aqueous biological samples, we combined the solution-gated graphene transistor (SGGT) with the catalytic reaction of enzyme nanoprobes (HRP-AuNPs-Ab2) to accurately sense AFP. The SGGT immunosensor demonstrated high specificity and stability, excellent selectivity, and excessive linearity over a range of 4 ng/mL to 500 ng/mL, with the lower detection limit down to 1.03 ng/mL. Finally, clinical samples were successfully detected by the SGGT immunosensor, and the results were consistent with chemiluminescence methods that are popular in hospitals for detecting AFP. Notably, the SGGT immunosensor is also recyclable, so it has excellent potential for use in high-throughput detection.

Indexed as

Biosensing TechniquesGraphiteMetal Nanoparticlesalpha-FetoproteinsElectrochemical TechniquesGoldHumansImmunoassayLimit of Detectionalpha-FetoproteinsGoldGraphiteAlpha-fetoproteinCatalytic nanoprobesClinical detectionSolution-gated graphene transistor

Identifiers

PMID37930375
OpenAlexW4388414841

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.