Evidence map›Paper›PMID 37930328›Full record

ArticleApplied and environmental microbiology2023

Enhancing the antibacterial function of probiotic

Emma Bartram, Masanori Asai, Philippe Gabant, Sivaramesh Wigneshweraraj

Open access · hybridAbstract read
In one paragraph

Article in Applied and environmental microbiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Emma BartramSection of Molecular Microbiology, Imperial College London , London, United Kingdom.ORCID 0009-0009-1915-1195
Masanori AsaiSection of Molecular Microbiology, Imperial College London , London, United Kingdom.
Philippe GabantSyngulon SA , Seraing, Belgium.
Sivaramesh WigneshwerarajSection of Molecular Microbiology, Imperial College London , London, United Kingdom.ORCID 0000-0002-1418-4029
Imperial College London · GB

Funding

National Centre for the Replacement, Refinement and Reduction of Animals in Research NC/W002264/1
6 · The paper itself

Abstract

Probiotic bacteria confer multiple health benefits, including preventing the growth, colonization, or carriage of harmful bacteria in the gut. Bacteriocins are antibacterial peptides produced by diverse bacteria, and their production is tightly regulated and coordinated at the transcriptional level. A popular strategy for enhancing the antibacterial properties of probiotic bacteria is to retrofit them with the ability to overproduce heterologous bacteriocins. This is often achieved from non-native constitutive promoters or in response to host or pathogen signal from synthetic promoters. How the dysregulated overproduction of heterologous bacteriocins affects the fitness and antibacterial efficacy of the retrofitted probiotic bacteria is often overlooked. We have conferred the prototypical probiotic

Indexed as

BacteriocinsEnterohemorrhagic Escherichia coliEscherichia coli ProteinsProbioticsAnti-Bacterial AgentsBacteriaAnti-Bacterial AgentsBacteriocinsEscherichia coli ProteinsEscherichia coli Nisslemicrocin Cprobioticspromoters

Identifiers

PMID37930328
PMCPMC10686094
OpenAlexW4388423670

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.