Evidence map›Paper›PMID 37929728›Full record

ArticleCombinatorial chemistry & high throughput screening2024

Combinatorial Synthesis of Indole Derivatives as Anti-oomycetes Agents.

Fei Hai, Ruxue Wei, Yan Li, Ruiguang Wang, Yuee Tian, Shengming Liu, Genqiang Chen, Zhiping Che

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Article in Combinatorial chemistry & high throughput screening, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Fei HaiCollege of Agricultural Engineering, Henan Vocational College of Agriculture, Zhengzhou 451450, Henan Province, China.
Ruxue WeiLaboratory of Pesticidal Design & Synthesis, Department of Plant Protection, College of Horticulture and Plant Protection, Henan University of Science and Technology, Luoyang 471023, China.
Yan LiLaboratory of Pesticidal Design & Synthesis, Department of Plant Protection, College of Horticulture and Plant Protection, Henan University of Science and Technology, Luoyang 471023, China.
Ruiguang WangLaboratory of Pesticidal Design & Synthesis, Department of Plant Protection, College of Horticulture and Plant Protection, Henan University of Science and Technology, Luoyang 471023, China.
Yuee TianLaboratory of Pesticidal Design & Synthesis, Department of Plant Protection, College of Horticulture and Plant Protection, Henan University of Science and Technology, Luoyang 471023, China.
Shengming LiuLaboratory of Pesticidal Design & Synthesis, Department of Plant Protection, College of Horticulture and Plant Protection, Henan University of Science and Technology, Luoyang 471023, China.
Genqiang ChenLaboratory of Pesticidal Design & Synthesis, Department of Plant Protection, College of Horticulture and Plant Protection, Henan University of Science and Technology, Luoyang 471023, China.
Zhiping CheLaboratory of Pesticidal Design & Synthesis, Department of Plant Protection, College of Horticulture and Plant Protection, Henan University of Science and Technology, Luoyang 471023, China.ORCID 0000-0001-9537-6235

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDeveloping high-efficiency and low-risk small-molecule green fungicide is the key to effective control of the plant pathogenic oomycetes. Indole is an important raw material for drug synthesis. Due to its unique structural skeleton, indole, and its derivatives have exhibited a wide range of biological activities. However, a study on the synthesis of novel indole derivatives as fungicidal agents against

methodsThe important intermediates 2a-c and 3a-c were synthesized in high yields by Vilsmeier- Haack and Knoevenagel reactions with indole as the lead compound. Furthermore, different substituted benzenesulfonyl groups were introduced into the NH position of the indole ring, and twelve indole derivatives (I-a-l) were prepared. Their structures were well characterized by

resultsThe results showed that 2-[(

conclusionThe preliminary structure-activity relationship showed that the formyl group modification at the C-3 position of the indole ring was acceptable, and the different anti-oomycete activities of R

Indexed as

IndolesAntifungal AgentsCombinatorial Chemistry TechniquesFungicides, IndustrialMolecular StructureOomycetesPhytophthoraStructure-Activity RelationshipAntifungal AgentsFungicides, IndustrialIndolesanti-oomycete activityindole derivativesindole synthesisNatural productPhytophthora capsiciplant secondary metabolites.

Identifiers

PMID37929728

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.