Evidence map›Paper›PMID 37929615›Full record

Observational studyCirculation2024

Associations Between End-Tidal Carbon Dioxide During Pediatric Cardiopulmonary Resuscitation, Cardiopulmonary Resuscitation Quality, and Survival.

Ryan W Morgan, Ron W Reeder, Dieter Bender, Kellimarie K Cooper, Stuart H Friess, Kathryn Graham, Kathleen L Meert, Peter M Mourani, Robert Murray, Vinay M Nadkarni and 9 more

Registry-linked trialOpen access · greenAbstract readObservational StudyMulticenter Study
In one paragraph

Observational study in Circulation, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02837497 (Improving Outcomes After Pediatric Cardiac Arrest), which is not on this map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
10.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02837497 nacompletednot on this map

Improving Outcomes After Pediatric Cardiac Arrest

TypeinterventionalSponsorChildren's Hospital of PhiladelphiaRan2016 to 2021Enrolled1,127ConditionsCardiac ArrestArmsICU-RESUS CPR Improvement Bundle
3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 30 citations in OpenAlex.

  1. Article
  2. Contemporary issues in pediatric prehospital airway management.Expert review of respiratory medicine · 2026
    Review
  3. Review
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Observational
  10. The Use of End-Tidal COJournal of clinical medicine · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 8 institutions in 1 country.

Ryan W MorganDepartment of Anesthesiology and Critical Care Medicine, The Children's Hospital of Philadelphia, University of Pennsylvania (R.W.M., K.K.C., K.G., V.M.N., H.A.W., R.A.B., R.M.S.).ORCID 0000-0003-1664-5316
Ron W ReederDepartment of Pediatrics, University of Utah, Salt Lake City (R.W.R., C.A.P.).ORCID 0000-0003-0021-5944
Dieter BenderVillanova Center for Analytics of Dynamic Systems, Villanova University, PA (D.B., C.N.).
Kellimarie K CooperDepartment of Anesthesiology and Critical Care Medicine, The Children's Hospital of Philadelphia, University of Pennsylvania (R.W.M., K.K.C., K.G., V.M.N., H.A.W., R.A.B., R.M.S.).
Stuart H FriessDepartment of Pediatrics, Washington University School of Medicine, St. Louis, MO (S.H.F.).ORCID 0000-0002-5854-5092
Kathryn GrahamDepartment of Anesthesiology and Critical Care Medicine, The Children's Hospital of Philadelphia, University of Pennsylvania (R.W.M., K.K.C., K.G., V.M.N., H.A.W., R.A.B., R.M.S.).ORCID 0000-0002-9435-7777
Kathleen L MeertDepartment of Pediatrics, Children's Hospital of Michigan, Central Michigan University, Detroit (K.L.M., B.T.).ORCID 0000-0002-4903-3503
Peter M MouraniDepartment of Pediatrics, University of Colorado School of Medicine and Children's Hospital Colorado, Aurora (P.M.M.).ORCID 0000-0002-1829-3775
Robert MurrayDepartment of Pediatrics, Nationwide Children's Hospital, The Ohio State University, Columbus (R.M., A.R.Y.).ORCID 0000-0003-0477-3791
Vinay M NadkarniDepartment of Anesthesiology and Critical Care Medicine, The Children's Hospital of Philadelphia, University of Pennsylvania (R.W.M., K.K.C., K.G., V.M.N., H.A.W., R.A.B., R.M.S.).ORCID 0000-0002-3794-5599
Chandrasekhar NatarajVillanova Center for Analytics of Dynamic Systems, Villanova University, PA (D.B., C.N.).
Chella A PalmerDepartment of Pediatrics, University of Utah, Salt Lake City (R.W.R., C.A.P.).ORCID 0009-0009-9376-4598
Neeraj SrivastavaDepartment of Pediatrics, Mattel Children's Hospital, University of California Los Angeles (N.S.).ORCID 0000-0002-5417-2786
Bradley TilfordDepartment of Pediatrics, Children's Hospital of Michigan, Central Michigan University, Detroit (K.L.M., B.T.).
Heather A WolfeDepartment of Anesthesiology and Critical Care Medicine, The Children's Hospital of Philadelphia, University of Pennsylvania (R.W.M., K.K.C., K.G., V.M.N., H.A.W., R.A.B., R.M.S.).ORCID 0000-0002-2760-6286
Andrew R YatesDepartment of Pediatrics, Nationwide Children's Hospital, The Ohio State University, Columbus (R.M., A.R.Y.).ORCID 0000-0003-2860-6808
Robert A BergDepartment of Anesthesiology and Critical Care Medicine, The Children's Hospital of Philadelphia, University of Pennsylvania (R.W.M., K.K.C., K.G., V.M.N., H.A.W., R.A.B., R.M.S.).ORCID 0000-0001-5529-9431
Robert M SuttonDepartment of Anesthesiology and Critical Care Medicine, The Children's Hospital of Philadelphia, University of Pennsylvania (R.W.M., K.K.C., K.G., V.M.N., H.A.W., R.A.B., R.M.S.).
ICU-RESUS and Eunice Kennedy Shriver National Institute of Child Health and Human Development Collaborative Pediatric Critical Care Research Network (CPCCRN) Investigator Groups
Children's Hospital of Philadelphia · USChildren's Hospital of Michigan · USNationwide Children's Hospital · USUniversity of Utah · USVillanova University · USChildren's Hospital Colorado · USMattel Children's Hospital · USWashington University in St. Louis · US

Funding

Data Coordinating Center for the Collaborative Pediatric Critical Care Research NetworkU01HD049934 · NICHD · UNIVERSITY OF UTAH · PI DEAN, JONATHAN MICHAEL · 2005 to 2020
$35.2M
CPCCRN PRECISE SupplementPL1HD105462 · NICHD · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Kevin M Watt · 2021 to 2026
$17.5M
Improving Outcomes after Pediatric Cardiac ArrestR01HL131544 · NHLBI · CHILDREN'S HOSP OF PHILADELPHIA · PI SUTTON, ROBERT MICHAEL · 2016 to 2020
$3.9M
Collaborative Pediatric Critical Care Research Network (CPCCRN) at Children's NationalUG1HD049981 · NICHD · CHILDREN'S RESEARCH INSTITUTE · PI POLLACK, MURRAY MICHAEL, WESSEL, DAVID LLOYD · 2015 to 2020
$1.8M
Pediatric Critical Care Research Network at Children's Hospital of PhiladelphiaUG1HD063108 · NICHD · CHILDREN'S HOSP OF PHILADELPHIA · PI BERG, ROBERT ALLEN, ZUPPA, ATHENA F. · 2015 to 2020
$1.7M
Collaborative Research to Validate Biomarkers of Pediatric ARDSUG1HD083166 · NICHD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MCQUILLEN, PATRICK SEAN, SAPRU, ANIL · 2015 to 2020
$1.6M
Renewal Application for the Childrens Hospital of Pittsburgh Collaborative Pediatric Critical Care Research Network SiteUG1HD049983 · NICHD · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CARCILLO, JOSEPH A · 2015 to 2020
$1.6M
Collaborative Pediatric Critical Care Research NetworkUG1HD050096 · NICHD · WAYNE STATE UNIVERSITY · PI MEERT, KATHLEEN L. · 2015 to 2020
$1.6M
Collaborative Network Study of Airway Microbiome and Host Responses in Pediatric Respiratory FailureUG1HD083171 · NICHD · UNIVERSITY OF COLORADO DENVER · PI CARPENTER, TODD C · 2015 to 2020
$1.5M
Collaborative Pediatric Critical Care Research Network (UG1)UG1HD083170 · NICHD · RESEARCH INST NATIONWIDE CHILDREN'S HOSP · PI HALL, MARK W · 2015 to 2020
$1.5M
Validation of Physiologic CPR Quality Using NOn-inVasive Waveform Analytics (CPR-NOVA)R01HL147616 · NHLBI · CHILDREN'S HOSP OF PHILADELPHIA · PI BERG, ROBERT ALLEN, SUTTON, ROBERT MICHAEL · 2019 to 2021
$1.2M
Collaborative Pediatric Critical Care Research Network - Clinical SiteRL1HD107773 · NICHD · CENTRAL MICHIGAN UNIVERSITY · PI KATHLEEN L. MEERT · 2021 to 2026
$862k
NHLBI NIH HHS K23 HL148541NHLBI NIH HHS R01 HL131544NHLBI NIH HHS R01 HL147616NICHD NIH HHS PL1 HD105462NICHD NIH HHS RL1 HD107773NICHD NIH HHS U01 HD049934NICHD NIH HHS UG1 HD049981NICHD NIH HHS UG1 HD049983NICHD NIH HHS UG1 HD050096NICHD NIH HHS UG1 HD063108NICHD NIH HHS UG1 HD083166NICHD NIH HHS UG1 HD083170NICHD NIH HHS UG1 HD083171
6 · The paper itself

Abstract

backgroundSupported by laboratory and clinical investigations of adult cardiopulmonary arrest, resuscitation guidelines recommend monitoring end-tidal carbon dioxide (ETCO

methodsThis prospective observational cohort study was a National Heart, Lung, and Blood Institute-funded ancillary study of children in the ICU-RESUS trial (Intensive Care Unit-Resuscitation Project; NCT02837497). Hospitalized children (≤18 years of age and ≥37 weeks postgestational age) who received chest compressions of any duration for cardiopulmonary arrest, had an endotracheal or tracheostomy tube at the start of CPR, and evaluable intra-arrest ETCO

resultsAmong 234 included patients, 133 (57%) had an event-level average ETCO

conclusionsIn this multicenter study of children with in-hospital cardiopulmonary arrest, ETCO

Indexed as

Cardiopulmonary ResuscitationHeart ArrestAdolescentCarbon DioxideChildHumansPatient DischargeProspective StudiesCarbon Dioxidecarbon dioxidecardiopulmonary resuscitationheart arrestintensive care units, pediatric

Identifiers

PMID37929615
PMCPMC10841728
OpenAlexW4388420925

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.