Evidence map›Paper›PMID 37929025›Full record

ArticleFrontiers in endocrinology2023

Elderly rats fed with a high-fat high-sucrose diet developed sex-dependent metabolic syndrome regardless of long-term metformin and liraglutide treatment.

Vedrana Ivić, Milorad Zjalić, Senka Blažetić, Matija Fenrich, Irena Labak, Rudolf Scitovski, Kálmán Ferenc Szűcs, Eszter Ducza, Tamás Tábi, Fruzsina Bagamery and 17 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in endocrinology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.8field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors at 6 institutions in 4 countries.

Vedrana Ivić *Department of Medical Biology and Genetics, Faculty of Medicine Osijek, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia.
Milorad Zjalić *Department of Medical Biology and Genetics, Faculty of Medicine Osijek, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia.
Senka BlažetićDepartment of Biology, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia.
Matija FenrichDepartment of Medical Biology and Genetics, Faculty of Medicine Osijek, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia.
Irena LabakDepartment of Biology, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia.
Rudolf ScitovskiSchool of Applied Mathematics and Computer Science, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia.
Kálmán Ferenc SzűcsDepartment of Pharmacology and Pharmacotherapy, Albert Szent-Györgyi Medical School, Interdisciplinary Excellence Centre, University of Szeged, Szeged, Hungary.
Eszter DuczaDepartment of Pharmacodynamics and Biopharmacy, Faculty of Pharmacy, University of Szeged, Szeged, Hungary.
Tamás TábiDepartment of Pharmacodynamics, Faculty of Pharmacy, Semmelweis University, Budapest, Hungary.
Fruzsina BagameryDepartment of Pharmacodynamics, Faculty of Pharmacy, Semmelweis University, Budapest, Hungary.
Éva SzökőDepartment of Pharmacodynamics, Faculty of Pharmacy, Semmelweis University, Budapest, Hungary.
Rosemary VukovićDepartment of Biology, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia.
Alen RončevićDepartment of Medical Biology and Genetics, Faculty of Medicine Osijek, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia.
Dario MandićClinical Institute of Laboratory Diagnostics, Osijek University Hospital, Osijek, Croatia.
Željko DebeljakClinical Institute of Laboratory Diagnostics, Osijek University Hospital, Osijek, Croatia.
Monika BereckiDepartment of Medical Biology and Genetics, Faculty of Medicine Osijek, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia.
Marta BalogDepartment of Medical Biology and Genetics, Faculty of Medicine Osijek, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia.
Adrienn Seres-BokorDepartment of Pharmacodynamics and Biopharmacy, Faculty of Pharmacy, University of Szeged, Szeged, Hungary.
Anita Sztojkov-IvanovDepartment of Pharmacodynamics and Biopharmacy, Faculty of Pharmacy, University of Szeged, Szeged, Hungary.
Judit Hajagos-TóthDepartment of Pharmacology and Pharmacotherapy, Albert Szent-Györgyi Medical School, Interdisciplinary Excellence Centre, University of Szeged, Szeged, Hungary.
Srećko GajovićCroatian Institute for Brain Research, and BIMIS - Biomedical Research Institute Šalata, University of Zagreb School of Medicine, Zagreb, Croatia.
Alen ImširovićDepartment of Medical Biology and Genetics, Faculty of Medicine Osijek, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia.
Marina BakulaDepartment of Clinical Pathology and Forensic Medicine, Osijek University Hospital, Osijek, Croatia.
Solomiia MahiiovychDepartment of Therapy № 1 and Medical Diagnostics, Hematology and Transfusiology, Faculty of Postgraduate Education, Danylo Halytsky Lviv National Medical University, Lviv, Ukraine.
Robert Gaspar *Department of Pharmacology and Pharmacotherapy, Albert Szent-Györgyi Medical School, Interdisciplinary Excellence Centre, University of Szeged, Szeged, Hungary.
Sandor G Vari *Cedars-Sinai Medical Center, International Research and Innovation in Medicine Program, Los Angeles, CA, United States.
Marija Heffer *Department of Medical Biology and Genetics, Faculty of Medicine Osijek, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia.
University of Osijek · HRUniversity of Szeged · HUSemmelweis University · HUCedars-Sinai Medical Center · USDanylo Halytsky Lviv National Medical University · UAUniversity of Zagreb · HR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aim/Introduction: The study aimed to determine the effectiveness of early antidiabetic therapy in reversing metabolic changes caused by high-fat and high-sucrose diet (HFHSD) in both sexes. Methods: Elderly Sprague-Dawley rats, 45 weeks old, were randomized into four groups: a control group fed on the standard diet (STD), one group fed the HFHSD, and two groups fed the HFHSD along with long-term treatment of either metformin (HFHSD+M) or liraglutide (HFHSD+L). Antidiabetic treatment started 5 weeks after the introduction of the diet and lasted 13 weeks until the animals were 64 weeks old. Results: Unexpectedly, HFHSD-fed animals did not gain weight but underwent significant metabolic changes. Both antidiabetic treatments produced sex-specific effects, but neither prevented the onset of prediabetes nor diabetes. Conclusion: Liraglutide vested benefits to liver and skeletal muscle tissue in males but induced signs of insulin resistance in females.

Indexed as

LiraglutideMetabolic SyndromeMetforminAnimalsFemaleHypoglycemic AgentsMaleRatsRats, Sprague-DawleySex FactorsSucroseHypoglycemic AgentsLiraglutideMetforminSucrosediabetes mellitushigh-fat high-sucrose dietinsulin resistancemetabolomicssex differences

Identifiers

PMID37929025
PMCPMC10623428
OpenAlexW4387809906

What OpenQuestion holds

Texttitle and abstract
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.