ArticleBrain, behavior, & immunity - health2023
Inflammatory biomarkers link perceived stress with metabolic dysregulation.
Article in Brain, behavior, & immunity - health, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.
- Determinants of Cardiovascular Disease Risk Among LGBTQ+ Populations: A Systematic Review of Empirical Evidence.Nursing open · 2026Pooled it
- Food Security and Cardio-Metabolic Risk in Individuals with Metabolic Syndrome.International journal of environmental research and public health · 2024Trial
- Candidate Biological Indicators of Occupational Stress in Healthcare Workers: Heart Rate, Free Triiodothyronine and HDL Cholesterol-A Cross-Sectional Study.Nursing reports (Pavia, Italy) · 2026Article
- Association Between Biochemical, Inflammatory, Oxidative Stress and DNA Methylation Biomarkers with Perceived Stress in Mexican Individuals.Biomolecules · 2026Article
- Immune cell dynamics and cytokine regulation in cornea and transplantation.Frontiers in immunology · 2026Review
- Complement Components C1r and C8 Serve as Potential Inflammatory Biomarkers for Coronary Heart Disease Severity: The Mediating Role of C-Reactive Protein.Journal of inflammation research · 2026Article
- Association of High-Sensitivity C-Reactive Protein with Metabolic Syndrome and Transitions in Metabolic Status: A Combined Cross-Sectional and Cohort Study with Gender Differences in Chinese Adults.Journal of inflammation research · 2026Article
- Cortisol-CXFrontiers in immunology · 2026Article
- Temporal dynamics of heart rate variability reveal stressor-specific autonomic patterns: a multi-stressor study.Frontiers in neuroscience · 2026Article
- Adverse Life Events Across the Life Course and the Risk of New-Onset Cardiovascular-Kidney-Metabolic Multimorbidity in Middle-Aged and Older Adults: Longitudinal Evidence From CHARLS.Journal of the American Heart Association · 2025Article
- Association between the stress hyperglycemia ratio and elevated blood pressure among U.S. adolescents aged 12-17.Cardiovascular diabetology · 2025Article
- Association of tooth loss with circadian syndrome in US adults: the mediated role of systemic inflammation.Clinical oral investigations · 2025Article
- Relating Biopsychosocial Meanings to Semi-Quantitative CRP Readings Among Primary Healthcare Users: Trends from a Cross-Sectional Study Analysis.Journal of clinical medicine · 2025Article
- Inflammation following childhood maltreatment is associated with episodic memory decline in older adults.Journal of traumatic stress · 2025Article
- Mental Health and Metabolic Outcomes in Early Postpartum in Women with Prediabetes After Gestational Diabetes: A Secondary Analysis of the MELINDA Trial.Journal of clinical medicine · 2025Article
- Regulation of Stress-Induced Immunosuppression in the Context of Neuroendocrine, Cytokine, and Cellular Processes.Biology · 2025Review
- Human immune and metabolic biomarker levels, and stress-biomarker associations, differ by season: Implications for biomedical health research.Brain, behavior, & immunity - health · 2024Article
- Emotion suppression differentially moderates the link between stress and cardiovascular disease risk in Japanese and Americans.International journal of clinical and health psychology : IJCHPArticle
- Income and Time Poverty and Metabolic Syndrome in Korea: Sex-Specific Patterns After Hierarchical Adjustment.Inquiry : a journal of medical care organization, provision and financingArticle
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: Perceived stress has been identified as a risk factor for metabolic syndrome. However, the intermediate pathways underlying this relationship are not well understood. Inflammatory responses may be one process by which stress leads to metabolic dysregulation. Prior work has shown that chronic stress is associated with elevated systemic inflammation and that altered inflammatory activity contributes to the pathogenesis of metabolic syndrome. The current analyses tested this hypothesis by examining inflammation as a pathway by which perceived stress affects metabolic health. Methods: Data from the Midlife in the United States Study (MIDUS) (N = 648; Mean age = 52.3) provided measures of perceived stress, inflammatory biomarkers [C-reactive protein (CRP), interleukin-6 (IL-6), E-selectin, fibrinogen, intracellular adhesion molecule-1 (ICAM-1)] and metabolic health markers. Confirmatory factor analysis (CFA) was used to confirm the fit of a hierarchical model of metabolic syndrome in our sample. Structural equation modeling (SEM) was used to test the assumption that inflammation mediates the association between perceived stress and the latent factor representing metabolic syndrome. Results: The CFA of metabolic syndrome demonstrated excellent goodness of fit to our sample [CFI = 0.97, TLI = 0.95, RMSEA = 0.06, SMSR = 0.05]. Mediation analysis with SEM revealed that the indirect pathway linking stress to metabolic dysregulation through inflammation was significant [ Conclusions: These results suggest that inflammatory biomarkers are a viable explanatory pathway for the relationship between perceived stress and metabolic health consequences. Interventions that target psychosocial stress may serve as cost-effective and accessible treatment options for mitigating inflammatory health risks.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.