Evidence map›Paper›PMID 37928731›Full record

ArticleFrontiers in neuroscience2023

Exploring the brain epitranscriptome: perspectives from the NSAS summit.

Sung-Min Lee, Bonsang Koo, Clément Carré, André Fischer, Chuan He, Ajeet Kumar, Kathy Liu, Kate D Meyer, Guo-Li Ming, Junmin Peng and 10 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in neuroscience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 15 institutions in 8 countries.

Sung-Min LeeDepartment of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Republic of Korea.
Bonsang KooDepartment of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Republic of Korea.
Clément CarréTransgenerational Epigenetics & Small RNA Biology, Centre National de la Recherche Scientifique, Laboratoire de Biologie du Développement - Institut de Biologie Paris Seine, Sorbonne Université, Paris, France.
André FischerDepartment for Epigenetics and Systems Medicine in Neurodegenerative Diseases, German Center for Neurodegenerative Diseases (DZNE), Göttingen, Germany.
Chuan HeDepartment of Chemistry, Howard Hughes Medical Institute, The University of Chicago, Chicago, IL, United States.
Ajeet KumarDepartment of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Republic of Korea.
Kathy LiuDepartment of Biochemistry and Biophysics, University of Pennsylvania, Philadelphia, PA, United States.
Kate D MeyerDepartment of Biochemistry, Duke University School of Medicine, Durham, NC, United States.
Guo-Li MingDepartment of Neuroscience and Mahoney Institute for Neurosciences, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States.
Junmin PengDepartment of Structural Biology, St. Jude Children's Research Hospital, Danny Thomas Place, Memphis, TN, United States.
Jean-Yves RoignantCenter for Integrative Genomics, Faculty of Biology and Medicine, University of Lausanne, Lausanne, Switzerland.
Erik StorkebaumDonders Institute for Brain, Cognition and Behaviour and Faculty of Science, Radboud University, Nijmegen, Netherlands.
Shuying SunDepartment of Physiology and Brain Science Institute, Johns Hopkins University School of Medicine, Baltimore, MD, United States.
Davide De Pietri TonelliNeurobiology of miRNA, Fondazione Istituto Italiano di Tecnologia (IIT), Genova, Italy.
Yinsheng WangDepartment of Chemistry, University of California, Riverside, CA, United States.
Yi-Lan WengDepartment of Neurosurgery, Houston Methodist Neurological Institute, Houston, TX, United States.
Luigi PulvirentiNeuroscience School of Advanced Studies, London, United Kingdom.
Yanhong ShiDepartment of Neurodegenerative Diseases, Beckman Research Institute of City of Hope, Duarte, CA, United States.
Ki-Jun YoonDepartment of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Republic of Korea.
Hongjun SongDepartment of Neuroscience and Mahoney Institute for Neurosciences, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States.
Korea Advanced Institute of Science and Technology · KRUniversity of Pennsylvania · USBeckman Research InstituteDuke University · USGerman Center for Neurodegenerative Diseases · DEHouston Methodist · USItalian Institute of Technology · ITJohns Hopkins Medicine · USRadboud University Nijmegen · NLSchool of Advanced Study · GBSorbonne Université · FRSt. Jude Children's Research Hospital · USUniversity of California, Riverside · USUniversity of Chicago · USUniversity of Lausanne · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Increasing evidence reinforces the essential function of RNA modifications in development and diseases, especially in the nervous system. RNA modifications impact various processes in the brain, including neurodevelopment, neurogenesis, neuroplasticity, learning and memory, neural regeneration, neurodegeneration, and brain tumorigenesis, leading to the emergence of a new field termed neuroepitranscriptomics. Deficiency in machineries modulating RNA modifications has been implicated in a range of brain disorders from microcephaly, intellectual disability, seizures, and psychiatric disorders to brain cancers such as glioblastoma. The inaugural NSAS Challenge Workshop on Brain Epitranscriptomics hosted in Crans-Montana, Switzerland in 2023 assembled a group of experts from the field, to discuss the current state of the field and provide novel translational perspectives. A summary of the discussions at the workshop is presented here to simulate broader engagement from the general neuroscience field.

Indexed as

epitranscriptomeglioblastomaneurodevelopmentneuroepitranscriptomicsneurogenesisRNA modifications

Identifiers

PMID37928731
PMCPMC10625424
OpenAlexW4387820290

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.