Evidence map›Paper›PMID 37928496›Full record

ArticleBioinformation2023

The lymphatic system: a pathway for meta-inflammation in permafrost immunity.

Francesco Chiappelli, Lily Fotovat

Abstract readEditorial
In one paragraph

Article in Bioinformation, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Francesco ChiappelliDental Group of Sherman Oaks, Sherman Oaks, CA 91403.
Lily FotovatDental Group of Sherman Oaks, Sherman Oaks, CA 91403.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The lymphatic system is the anatomical substratum of immunity. Lymphatics collect tissue exudates, which contain cell debris, peptides, micronutrients and pathogens, as well as immune naive and memory effector cells from the body tissues and organs into the lymph. Lined by endothelial cells cemented together by tight junctions to ensure their impermeability, lymphatics contain valves that prevent the backward flow of the lymph as it moves forward toward the right and left venous angles, the anatomical site of confluence with the venous blood. Meta-inflammation increases the permeability of lymphatics, rendering the elderly more susceptible to novel and ancient airborne viruses released by melting glaciers and permafrost. Simple public health protocols (e.g., mask-wearing, quarantine) are essential to minimize colliding epidemics/pandemics, and favor permafrost immunity.

Indexed as

inflamm-agingLymphaticsmeta-inflammationpandemicpermafrost pathogenspro-inflammatory cytokinespublic health

Identifiers

PMID37928496
PMCPMC10625371

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.