Evidence map›Paper›PMID 37928277›Full record

ArticleIJU case reports2023

Two cases of prostate cancer with disseminated carcinomatosis of the bone marrow treated with novel hormonal agents.

Keina Nozaki, Hisashi Matsushima, Hiyo Obikane, Ryohei Nishimoto, Ryo Tanaka, Takeru Morishige, Tomoko Masuda, Haruki Kume

Open access · goldAbstract readCase Reports
In one paragraph

Article in IJU case reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.3field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Keina NozakiDepartment of Urology Tokyo Metropolitan Police Hospital Tokyo Japan.ORCID https://orcid.org/0000-0002-0268-3090
Hisashi MatsushimaDepartment of Urology Tokyo Metropolitan Police Hospital Tokyo Japan.
Hiyo ObikaneDepartment of Diagnostic Pathology Tokyo Metropolitan Police Hospital Tokyo Japan.
Ryohei NishimotoDepartment of Urology Tokyo Metropolitan Police Hospital Tokyo Japan.
Ryo TanakaDepartment of Urology Tokyo Metropolitan Police Hospital Tokyo Japan.
Takeru MorishigeDepartment of Urology Tokyo Metropolitan Police Hospital Tokyo Japan.
Tomoko MasudaDepartment of Urology Tokyo Metropolitan Police Hospital Tokyo Japan.
Haruki KumeDepartment of Urology The University of Tokyo Graduate School of Medicine Tokyo Japan.ORCID https://orcid.org/0000-0001-9841-0857
Tokyo Metropolitan Police Hospital · JPThe University of Tokyo · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Disseminated carcinomatosis of the bone marrow in prostate cancer is rare and has a poor prognosis. Although strong evidence suggests that novel hormonal agents improve the prognosis of metastatic prostate cancer, their effectiveness in cases of disseminated carcinomatosis of the bone marrow remains unclear. Case presentation: We encountered two cases of prostate cancer with disseminated carcinomatosis of the bone marrow at the time of initial diagnosis. One patient was treated with enzalutamide, abiraterone, docetaxel, cabazitaxel, denosumab, and radium-223 and died 38 months after the initial diagnosis. The other patient was treated with apalutamide and denosumab, and had progression-free survival for 17 months after the initial diagnosis. Conclusion: These results suggest that novel hormonal agents may improve the prognosis of prostate cancer even in patients with disseminated carcinomatosis of the bone marrow.

Indexed as

androgen receptor‐axis targeted agentsbone marrow involvementbone marrow metastasisnew hormonal agentsradium‐223

Identifiers

PMID37928277
PMCPMC10622209
OpenAlexW4385581112

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.