Evidence map›Paper›PMID 37928212›Full record

ArticleWellcome open research2023

BurkHostGEN: a study protocol for evaluating variations in the

Kesorn Angchagun, Phumrapee Boonklang, Chalita Chomkatekaew, Sukritpong Pakdeerat, Gumphol Wongsuwan, Premjit Amornchai, Vanaporn Wuthiekanun, Salwaluk Panapipat, Thatsanun Ngernseng, Naomi Waithira and 15 more

Abstract read
In one paragraph

Article in Wellcome open research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors.

Kesorn AngchagunMahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Salaya, Nakhon Pathom, 10400, Thailand.
Phumrapee BoonklangMahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Salaya, Nakhon Pathom, 10400, Thailand.ORCID https://orcid.org/0000-0002-9444-2103
Chalita ChomkatekaewMahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Salaya, Nakhon Pathom, 10400, Thailand.ORCID https://orcid.org/0000-0003-2543-1045
Sukritpong PakdeeratMahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Salaya, Nakhon Pathom, 10400, Thailand.
Gumphol WongsuwanMahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Salaya, Nakhon Pathom, 10400, Thailand.
Premjit AmornchaiMahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Salaya, Nakhon Pathom, 10400, Thailand.
Vanaporn WuthiekanunMahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Salaya, Nakhon Pathom, 10400, Thailand.ORCID https://orcid.org/0000-0002-3074-0742
Salwaluk PanapipatMahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Salaya, Nakhon Pathom, 10400, Thailand.
Thatsanun NgernsengMahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Salaya, Nakhon Pathom, 10400, Thailand.ORCID https://orcid.org/0000-0002-1627-700X
Naomi WaithiraMahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Salaya, Nakhon Pathom, 10400, Thailand.ORCID https://orcid.org/0000-0002-2267-9347
Steve WaltonWellcome Sanger Institute, Hinxton, England, CB10 1SA, UK.
Direk LimmathurotsakulMahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Salaya, Nakhon Pathom, 10400, Thailand.ORCID https://orcid.org/0000-0001-7240-5320
Anoree SurawongSunpasitthiprasong Regional Hospital, Ubon Ratchathani, 34000, Thailand.
Suwatthiya SiriboonSunpasitthiprasong Regional Hospital, Ubon Ratchathani, 34000, Thailand.
Parinya ChamnanSunpasitthiprasong Regional Hospital, Ubon Ratchathani, 34000, Thailand.ORCID https://orcid.org/0000-0002-5202-4149
Narisara ChantratitaDepartment of Microbiology and Immunology, Faculty of Tropical Medicine, Mahidol University, Salaya, Nakhon Pathom, 10400, Thailand.
Susie DunachieNuffield Department of Medicine, Centre of Tropical Medicine and Global Health, University of Oxford, Oxford, England, OX3 7LG, UK.ORCID https://orcid.org/0000-0001-5665-6293
Jukka CoranderWellcome Sanger Institute, Hinxton, England, CB10 1SA, UK.ORCID https://orcid.org/0000-0002-7752-1942
Emma E DavenportWellcome Sanger Institute, Hinxton, England, CB10 1SA, UK.
Julian KnightWellcome Centre for Human Genetics, University of Oxford, Oxford, England, OX3 7BN, UK.
Julian ParkhillDepartment of Veterinary Medicine, University of Cambridge, Cambridge, England, CB3 0ES, UK.ORCID https://orcid.org/0000-0002-7069-5958
Sharon J PeacockDepartment of Medicine, University of Cambridge, Cambridge, England, CB2 0SP, UK.
Nicholas R ThomsonWellcome Sanger Institute, Hinxton, England, CB10 1SA, UK.
Nicholas P J DayMahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Salaya, Nakhon Pathom, 10400, Thailand.ORCID https://orcid.org/0000-0003-2309-1171
Claire ChewapreechaMahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Salaya, Nakhon Pathom, 10400, Thailand.

Funding

Wellcome Trust
6 · The paper itself

Abstract

Background: Melioidosis is a frequently fatal disease caused by an environmental bacterium Methods: BurkHostGEN is an ongoing observational study being conducted at Sunpasitthiprasong Hospital, Ubon Ratchathani, Thailand. We are obtaining consent from 600 melioidosis patients and 700 controls, spanning both sexes, to collect 1 mL of blood for host DNA analysis, 3 mL of blood for RNA analysis, as well as 5 L of household water supply for metagenomic analysis. Additionally, we are isolating Conclusions: BurkHostGEN holds the potential to discover bacterial and host genetic factors associated with melioidosis infection and severity of illness. It can also support various study designs, including biomarker validation, disease pathogenesis, and epidemiological analysis not only for melioidosis but also for other infectious diseases.

Indexed as

bioresourcesdiagnosticsepidemiologygenomicsmelioidosismicrobiology

Identifiers

PMID37928212
PMCPMC10624953

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.