ArticleFrontiers in neurology2023
Proof-of-concept for characterization of neurodegenerative disorders utilizing two non-REM sleep biomarkers.
Article in Frontiers in neurology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 7 citations in OpenAlex.
- Smart Wearable EEG Devices: A Review of Lightweight, Multi-Sensor Systems for Sleep and Everyday Neurophysiology.Biosensors · 2026Review
- Can objective measures of physical activity and sleep serve as early predictors of dementia among individuals with cognitive impairment?medRxiv : the preprint server for health sciences · 2025Article
- SLEEP AND NEURODEGENERATION: EXAMINING POTENTIAL PHYSIOLOGICAL MECHANISMS.Current sleep medicine reports · 2025Article
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- Transforming Sleep Monitoring: Review of Wearable and Remote Devices Advancing Home Polysomnography and Their Role in Predicting Neurological Disorders.Biosensors · 2025Review
- Concordance and test-retest consistency of sleep biomarker-based neurodegenerative disorder profiling.Scientific reports · 2024Article
- Autonomic dysregulation during sleep in Parkinsonian spectrum disorders - A proof of concept.Parkinsonism & related disorders · 2023Article
Corrections and comments
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Authors and funding
11 authors at 6 institutions in 1 country.
Funding
Abstract
Study objective: This proof-of-concept study aimed to determine whether the combined features of two non-rapid eye movement (NREM) sleep biomarkers acquired predominantly in-home could characterize different neurodegenerative disorders. Methods: Sleep spindle duration and non-REM hypertonia (NRH) were evaluated in seven groups including a control group (CG = 61), and participants with isolated REM sleep behavior disorder (iRBD = 19), mild cognitive impairment (MCI = 41), Parkinson disease (PD = 16), Alzheimer disease dementia (ADem = 29), dementia with Lewy Bodies or Parkinson disease dementia (LBD = 19) and progressive supranuclear palsy (PSP = 13). One-way analysis of variance (ANOVA), Mann-Whitney Results: ANOVA identified group differences in age, sleep efficiency, REM, NRH ( Conclusion: The NREM sleep biomarkers spindle duration and NRH may be useful in distinguishing patients with different neurodegenerative disorders. Larger prospective cohort studies are needed to determine whether spindle duration and NRH can be combined for prodromal assessment and/or monitoring disease progression.
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