Evidence map›Paper›PMID 37928048›Full record

ArticleHeliyon2023

HCV treatment outcome depends on SNPs of IFNL3-Gene polymorphisms (rs12979860) and cirrhotic changes in liver parenchyma.

Mohamed Darwish Ahmed Abd Alla, Reham M Dawood, Hassan Abd El-Hafeth Rashed, Yasser Mohammed El-Dessouky, Galal AbdElhameed AbuFarrag, Islam Abdelmawla Emran Ammar, Mohamed Mahmoud Abdel-Halim Mahmoud, Ghada M Salum, Mohamed Zakaria Abu-Amer, Mohamed Abd Elrafaa Hassan Sekeen and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Heliyon, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. MMP-9 and non-invasive markers in evaluating MASLD and atherosclerosis.Journal, genetic engineering & biotechnology · 2026
    Article
  2. Frequencies of anInternational journal of molecular sciences · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 1 country.

Mohamed Darwish Ahmed Abd AllaDepartment of Hepatology, Gastroenterology and Infectious Diseases, Faculty of Medicine, Al-Azhar University, Egypt.
Reham M DawoodDepartment of Microbial Biotechnology, National Research Centre, Cairo, Egypt.
Hassan Abd El-Hafeth RashedDepartment of Hepatology, Gastroenterology and Infectious Diseases, Faculty of Medicine, Al-Azhar University, Egypt.
Yasser Mohammed El-DessoukyDepartment of Hepatology, Gastroenterology and Infectious Diseases, Faculty of Medicine, Al-Azhar University, Egypt.
Galal AbdElhameed AbuFarragDepartment of Hepatology, Gastroenterology and Infectious Diseases, Faculty of Medicine, Al-Azhar University, Egypt.
Islam Abdelmawla Emran AmmarDepartment of Hepatology, Gastroenterology and Infectious Diseases, Faculty of Medicine, Al-Azhar University, Egypt.
Mohamed Mahmoud Abdel-Halim MahmoudDepartment of Hepatology, Gastroenterology and Infectious Diseases, Faculty of Medicine, Al-Azhar University, Egypt.
Ghada M SalumDepartment of Microbial Biotechnology, National Research Centre, Cairo, Egypt.
Mohamed Zakaria Abu-AmerDepartment of Hepatology, Gastroenterology and Infectious Diseases, Faculty of Medicine, Al-Azhar University, Egypt.
Mohamed Abd Elrafaa Hassan SekeenDepartment of Hepatology, Gastroenterology and Infectious Diseases, Faculty of Medicine, Al-Azhar University, Egypt.
Mohamed Mousa Ibraheem HeggazyDepartment of Hepatology, Gastroenterology and Infectious Diseases, Faculty of Medicine, Al-Azhar University, Egypt.
Ahmed Mohamed Abdulhamid AltanboulyDepartment of Hepatology, Gastroenterology and Infectious Diseases, Faculty of Medicine, Al-Azhar University, Egypt.
Mai Abd El-MeguidDepartment of Microbial Biotechnology, National Research Centre, Cairo, Egypt.
Mostafa K El AwadyDepartment of Microbial Biotechnology, National Research Centre, Cairo, Egypt.
Al-Azhar University · EGNational Research Centre · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The allelic discrimination of IFNL3-(rs12979860 C > T) polymorphism reveals ambiguous associations with the effectiveness of oral HCV treatment. Solitary intra peripheral-blood-mononuclear-cells (PBMCs) HCV-RNA antisense-strands are independently detected in naïve and experienced cases regardless of viremia or hepatic-parenchymal alterations. We examined the frequencies of IFNL3-genetic variants with chronic-HCV-induced liver changes during the sustained virologic response (SVR) by evaluating the PBMCs- HCV-PCR after oral antiviral therapy.

Indexed as

DAAsHCV-Hepatic-changesIFNL3-Gene-SNPsPBMCs-PCR

Identifiers

PMID37928048
PMCPMC10623284
OpenAlexW4387777711

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.