Evidence map›Paper›PMID 37928042›Full record

ArticleHeliyon2023

The protective effect of allium cepa against ethylene glycol-induced kidney stones in rats.

Reham M Wahid, Nancy Husseiny Hassan, Walaa Samy, Eman Mahmoud Faragallah, Nanees F El-Malkey, Aliaa Talaat, Alia Ghoneum, Dara Aldisi, Mahmoud M Malek

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Heliyon, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.3field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Open veterinary journal · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 3 countries.

Reham M WahidPhysiology, Faculty of Medicine, Zagazig University, Egypt.
Nancy Husseiny HassanHuman Anatomy and Embryology, Faculty of Medicine, Zagazig University, Egypt.
Walaa SamyMedical Biochemistry, Faculty of Medicine, Zagazig University, Egypt.
Eman Mahmoud FaragallahPhysiology, Faculty of Medicine, Zagazig University, Egypt.
Nanees F El-MalkeyPhysiology, Faculty of Medicine, Zagazig University, Egypt.
Aliaa TalaatMedical Biochemistry, Faculty of Medicine, Zagazig University, Egypt.
Alia GhoneumSchool of Medicine, Wake Forest University, Winston Salem, NC, USA.
Dara AldisiCommunity Health Sciences Department, College of Applied Medical Sciences, King Saud University, Riyadh 11433, Saudi Arabia.
Mahmoud M MalekUrology and Andrology, Faculty of Medicine, Zagazig University, Egypt.
Zagazig University · EGKing Saud University · SAWake Forest University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

1Background: Kidney stones is one of the serious medical conditions affecting populations worldwide. So, we aimed in this study to investigate the protective effect of allium cepa administration against KSD. 2Methods: 24 adult male albino rats were assigned into 3 groups; group I: control group; group II: received ethylene glycol (EG) in the drinking water for 4 weeks; and group III received EG in the drinking water plus freshly prepared allium cepa extract (ACE) for 4 weeks. Renal function tests and urine analysis were done. Tissue oxidative stress markers (SOD and MDA) were assessed, and kidney expression of SIRT-1, Beclin, LC3, osteopontin, and Regucalcin were measured by RT-qPCR. Histopathological assessment and immunohistochemistry for Bax, Beclin-1 and TNF-α were performed. 3Results: There was a significant improved kidney function tests in the ACE received group compared to EG group (P < 0.001). The present study showed less stones formation and apoptosis with decreased osteopontin and autophagy genes expression in the ACE received group compared to EG group (P < 0.001). While, regucalcin and SIRT-1 genes showed higher expression in the former group than the later group (P < 0.001). 4 Conclusion: Alium Cepa extract administration has a significant protective effect against kidney stones formation.

Indexed as

allium cepaAutophagyInflammatory markersKidney stonesOsteopontinOxidative stress

Identifiers

PMID37928042
PMCPMC10623283
OpenAlexW4387826873

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.