Evidence map›Paper›PMID 37927899›Full record

ReviewBioactive materials2024

Decellularized extracellular matrix biomaterials for regenerative therapies: Advances, challenges and clinical prospects.

Aleksandra A Golebiowska, Jonathon T Intravaia, Vinayak M Sathe, Sangamesh G Kumbar, Syam P Nukavarapu

Abstract readReview
In one paragraph

Review in Bioactive materials, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 138 papers.

0numbers the graph read from it
0cells of the map it votes in
138citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

138 citing papers in PubMed.

  1. Article
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  7. Decellularized cardiac ECM: A tissue-specific bioactive platform for drug release and cell delivery.Journal of controlled release : official journal of the Controlled Release Society · 2026
    Review
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78 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Aleksandra A GolebiowskaDepartment of Biomedical Engineering, University of Connecticut, Storrs, CT, 06269, USA.
Jonathon T IntravaiaDepartment of Biomedical Engineering, University of Connecticut, Storrs, CT, 06269, USA.
Vinayak M SatheDepartment of Orthopaedic Surgery, University of Connecticut Health, Farmington, CT, 06032, USA.
Sangamesh G KumbarDepartment of Biomedical Engineering, University of Connecticut, Storrs, CT, 06269, USA.
Syam P NukavarapuDepartment of Biomedical Engineering, University of Connecticut, Storrs, CT, 06269, USA.

Funding

Biodegradable Matrices for Bone HealingR01EB020640 · NIBIB · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI KUMBAR, SANGAMESH GURAPPA, YU, XIAOJUN · 2017 to 2020
$1.6M
Biodegradable Matrices with Structural and Physical Cues for Interface EngineeringR01EB030060 · NIBIB · UNIVERSITY OF CONNECTICUT STORRS · PI NUKAVARAPU, SYAM · 2020 to 2024
$1.4M
NIBIB NIH HHS R01 EB020640NIBIB NIH HHS R01 EB030060
6 · The paper itself

Abstract

Tissue engineering and regenerative medicine have shown potential in the repair and regeneration of tissues and organs via the use of engineered biomaterials and scaffolds. However, current constructs face limitations in replicating the intricate native microenvironment and achieving optimal regenerative capacity and functional recovery. To address these challenges, the utilization of decellularized tissues and cell-derived extracellular matrix (ECM) has emerged as a promising approach. These biocompatible and bioactive biomaterials can be engineered into porous scaffolds and grafts that mimic the structural and compositional aspects of the native tissue or organ microenvironment, both

Indexed as

Bio-chemical cuesChemotactic abilityClinical therapiesNative micro-environmentNon-immune biomaterials and graftsTissue-inks

Identifiers

PMID37927899
PMCPMC10622743

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.