ArticleCureus2023
Association of Serum Bilirubin and Lipid Ratio (Total Cholesterol/(High-Density Lipoprotein + Bilirubin)) in Coronary Artery Disease: A Case-Control Study at a Tertiary Care Hospital.
Article in Cureus, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
4 citing papers in PubMed, 4 citations in OpenAlex.
- Association Between Serum Lipid-Bilirubin Ratio and Clinical Prognosis Among Patients Undergoing Percutaneous Coronary Intervention After Coronary Artery Bypass Grafting.Reviews in cardiovascular medicine · 2025Article
- Systematic Review and Meta-Analysis to Explore the Relationship of Increased Homocysteine, Lipid Levels and Lipid Ratios In-Cad.Journal of pharmacy & bioallied sciences · 2025Review
- Association between LDL/HDL ratio and hypertension in Chinese middle-aged and older adults: a cross-sectional and longitudinal analysis based on CHARLS LDL/HDL ration and hypertension.Frontiers in endocrinology · 2025Article
- Association Between Pericoronary Fat Attenuation Index as Evaluated by Coronary Artery CT Angiography and Clinical Interventions in Lipid Management Among Patients with Coronary Artery Disease.International journal of general medicine · 2024Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionCoronary artery disease (CAD) is a leading cause of morbidity and mortality worldwide, particularly in industrialized societies. The aim of the study was to investigate the potential association between lipid ratios and CAD risk and explore their diagnostic performance compared to traditional lipid profile parameters and total bilirubin levels.
methodsA total of 50 cases with CAD and 50 controls without CAD were recruited. Clinical data, including age, gender, comorbidities, blood pressure, glucose levels, smoking history, cardiovascular examination findings, and electrocardiogram (ECG) results, were collected. Lipid profile parameters (total cholesterol (TC), high-density lipoproteins (HDL), low-density lipoproteins (LDL), and triglycerides) and total bilirubin levels were measured. Lipid ratios, including cholesterol (CHO)/HDL, LDL/HDL, HDL + bilirubin, LDL/(HDL + bilirubin), and TC/(HDL + bilirubin), were calculated.
resultsSignificant differences were observed between cases and controls for comorbidities, including hypertension, diabetes, and obesity (p = 0.025), and ECG findings (p < 0.001). Lipid profile parameters were significantly different between cases and controls (p < 0.001). Lipid ratios also showed significant differences (p < 0.001) and demonstrated high sensitivity and specificity in identifying CAD. Among the ratios, LDL/HDL had the highest area under the curve (AUC) of 0.977, followed by CHO/HDL (AUC = 0.913), LDL/(HDL + bilirubin) (AUC = 0.903), and TC/(HDL + bilirubin) (AUC = 0.807). Total bilirubin alone did not show a significant association with CAD (AUC = 0.590, p = 0.119).
conclusionLipid ratios (CHO/HDL, LDL/HDL, HDL + bilirubin, LDL/(HDL + bilirubin), and TC/(HDL + bilirubin)) showed promising potential as predictors of CAD, outperforming traditional lipid profile parameters and total bilirubin levels. These ratios could serve as valuable diagnostic tools in identifying individuals at higher risk of CAD.
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