Evidence map›Paper›PMID 37927487›Full record

ArticleJIMD reports2023

Investigation of the relationship between phenylalanine in venous plasma and capillary blood using volumetric blood collection devices.

Rachel S Carling, Zoe Barclay, Nathan Cantley, Erin C Emmett, Sarah L Hogg, Yael Finezilber, Danja Schulenburg-Brand, Elaine Murphy, Stuart J Moat

Open access · goldAbstract read
In one paragraph

Article in JIMD reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 8 citations in OpenAlex.

  1. Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 2 countries.

Rachel S CarlingGKT School Medical Education Kings College London London UK.ORCID https://orcid.org/0000-0003-1988-3088
Zoe BarclayBiochemical Sciences, Synnovis, Guys & St Thomas' NHSFT London UK.
Nathan CantleyDepartment of Clinical Biochemistry, Severn Pathology Southmead Hospital, North Bristol NHS Trust Bristol UK.
Erin C EmmettBiochemical Sciences, Synnovis, Guys & St Thomas' NHSFT London UK.
Sarah L HoggBiochemical Genetics Unit Cambridge University Hospitals Cambridge UK.
Yael FinezilberCharles Dent Metabolic Unit National Hospital for Neurology and Neurosurgery, Queen Square London UK.
Danja Schulenburg-BrandDepartment of Haematology, Immunology and Metabolic Medicine University Hospital Wales Cardiff UK.
Elaine MurphyCharles Dent Metabolic Unit National Hospital for Neurology and Neurosurgery, Queen Square London UK.
Stuart J MoatDepartment of Medical Biochemistry, Immunology & Toxicology University Hospital Wales Cardiff UK.
Guy's and St Thomas' NHS Foundation Trust · GBNational Hospital for Neurology and Neurosurgery · GBUniversity Hospital of Wales · GBCambridge University Hospitals NHS Foundation Trust · GBKing's College - North Carolina · USNorth Bristol NHS Trust · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Measurement of plasma and dried blood spot (DBS) phenylalanine (Phe) is key to monitoring patients with phenylketonuria (PKU). The relationship between plasma and capillary DBS Phe concentrations has been investigated previously, however, differences in methodology, calibration approach and assumptions about the volume of blood in a DBS sub-punch has complicated this. Volumetric blood collection devices (VBCDs) provide an opportunity to re-evaluate this relationship. Paired venous and capillary samples were collected from patients with PKU (

Indexed as

DBSdried blood spotsmicrosamplingphenylalaninephenylketonuriaPKUstandardisationvolumetric blood collection devices

Identifiers

PMID37927487
PMCPMC10623100
OpenAlexW4387663412

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.