Evidence map›Paper›PMID 37927048›Full record

ArticlePlatelets2023

α-Synuclein is the major platelet isoform but is dispensable for activation, secretion, and thrombosis.

Alexis N Smith, Smita Joshi, Harry Chanzu, Hammodah R Alfar, Kanakanagavalli Shravani Prakhya, Sidney W Whiteheart

Open access · goldAbstract read
In one paragraph

Article in Platelets, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.6field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Alexis N SmithDepartment of Molecular and Cellular Biochemistry, College of Medicine, University of Kentucky, Lexington, KY, USA.
Smita JoshiDepartment of Molecular and Cellular Biochemistry, College of Medicine, University of Kentucky, Lexington, KY, USA.
Harry ChanzuDepartment of Molecular and Cellular Biochemistry, College of Medicine, University of Kentucky, Lexington, KY, USA.
Hammodah R AlfarDepartment of Molecular and Cellular Biochemistry, College of Medicine, University of Kentucky, Lexington, KY, USA.
Kanakanagavalli Shravani PrakhyaDepartment of Molecular and Cellular Biochemistry, College of Medicine, University of Kentucky, Lexington, KY, USA.
Sidney W WhiteheartDepartment of Molecular and Cellular Biochemistry, College of Medicine, University of Kentucky, Lexington, KY, USA.ORCID 0000-0001-5577-0473
University of Kentucky · US

Funding

Platelet Exocytosis and Endocytosis in Thrombosis and ImmunityR35HL150818 · NHLBI · UNIVERSITY OF KENTUCKY · PI SIDNEY Waldo WHITEHEART · 2020 to 2026
$6.5M
MOLECULAR MECHANISMS OF PLATELET EXOCYTOSISR01HL056652 · NHLBI · UNIVERSITY OF KENTUCKY · PI WHITEHEART, SIDNEY WALDO · 1996 to 2019
$5.2M
Platelet Endocytosis in Innate ImmunityR01HL138179 · NHLBI · UNIVERSITY OF KENTUCKY · PI WHITEHEART, SIDNEY WALDO · 2017 to 2019
$1.3M
Targeting Platelet Endocytosis and Exocytosis to Control ThrombosisI01BX003877 · VA · VA MEDICAL CENTER - LEXINGTON, KY · PI WHITEHEART, SIDNEY WALDO · 2018 to 2022
–
BLRD VA I01 BX003877NHLBI NIH HHS R01 HL056652NHLBI NIH HHS R01 HL138179NHLBI NIH HHS R35 HL150818
6 · The paper itself

Abstract

Platelets play many roles in the vasculature ensuring proper hemostasis and maintaining integrity. These roles are facilitated, in part, by cargo molecules released from platelet granules via

Indexed as

alpha-SynucleinThrombosisAnimalsBlood PlateletsCytoplasmic GranulesExocytosisMiceMice, KnockoutPlatelet ActivationProtein IsoformsSNARE Proteinsalpha-SynucleinProtein IsoformsSNARE ProteinsSnca protein, mouseExocytosishemostasisplateletsVAMPα-synuclein

Identifiers

PMID37927048
PMCPMC10629845
OpenAlexW4388419453

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.