ArticleBMC geriatrics2023
Neuroticism, physical activity, and cognitive functioning in a population-based cohort of older adults.
Article in BMC geriatrics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Association between neuroticism and physical activity: a systematic review and meta-analysis.Frontiers in human neuroscience · 2025Pooled it
- Association of neuroticism with incident dementia and cognitive function: 26-year follow-up of EPIC-Norfolk study.Age and ageing · 2025Article
- Five-factor model personality traits and cognition in the Harmonized Cognitive Assessment Protocol sub-study of the Survey of Health, Ageing, and Retirement in Europe.International journal of personality psychology · 2025Article
- Effects of neuroticism on pre-exam irritable bowel syndrome in female middle school students: mediating role of intolerance of uncertainty and moderating role of exercise duration.Frontiers in psychiatry · 2024Article
- Association between personality traits and concerns about falling among older patients: the mediating role of subjective age.Frontiers in public health · 2024Article
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Authors and funding
6 authors.
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Abstract
backgroundLittle is known about how physical activity influences the relationship between neuroticism and cognitive function and cognitive decline.
methodsData from the Chicago Health and Aging Project (CHAP) was utilized to conduct this study. CHAP is a population-based cohort study of chronic conditions in older adults. Participants completed in-home interviews cycles of three years from 1993-2012. Mixed effects regression models were conducted to test the associations between physical activity, neuroticism, and the interaction between neuroticism and physical activity on outcomes: global cognitive function, global cognitive decline, episodic memory, decline in episodic memory, perceptual speed, and decline in perceptual speed. Stratified mixed effects regression models by physical activity level were conducted to test the associations between neuroticism and global cognitive function and global cognitive decline.
resultsA total of 7,685 participants were eligible for this study. Participants were 62% female and 64% African American. We found statistically significant associations for the interaction of high physical activity and neuroticism on baseline global cognitive function (β = 0.017 (SE = 0.007), p = .010) and on the interaction of neuroticism and high physical activity on baseline episodic memory (β = 0.020 (SE = .009), p = .021) and on decline in episodic memory over time (β = -0.003 (SE = .001), p = .039).
conclusionHigher physical activity lessened the association between higher neuroticism and poor cognitive outcomes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.