Evidence map›Paper›PMID 37926822›Full record

ArticleBMC endocrine disorders2023

Atypical presentations of primary acquired hypothyroidism - a case series.

R R Pravin, Sheau Yun Kan, Ser Yee Soh, Daniel Chan, Rashida Farhad Vasanwala

Abstract readCase Reports
In one paragraph

Article in BMC endocrine disorders, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

R R PravinGeneral Paediatrics, KK Women's & Children's Hospital, Singapore, Singapore. rr.pravin@mohh.com.sg.ORCID http://orcid.org/0000-0003-4346-6188
Sheau Yun KanGeneral Paediatrics, KK Women's & Children's Hospital, Singapore, Singapore.
Ser Yee SohGeneral Paediatrics, KK Women's & Children's Hospital, Singapore, Singapore.
Daniel ChanYong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.ORCID http://orcid.org/0000-0001-8191-5330
Rashida Farhad VasanwalaYong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.ORCID http://orcid.org/0000-0002-3516-4203

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Primary acquired hypothyroidism in children manifests with a myriad of clinical presentations. Clinical features can be insidious in nature, often under the guise of non-specific presentations to other subspecialties prior to referral to the endocrinologist. Growth failure is a hallmark feature in these children alongside their presenting clinical symptomology which needs to be identified through detailed history, physical examination and analysis of the growth charts. In this case series, we discuss 5 atypical presentations of acquired primary hypothyroidism with multisystemic involvement, including musculoskeletal, hepatobiliary, gynaecological and haematological manifestations. This is of importance as untreated hypothyroidism leads to fatigue, decreased physical activity, suboptimal height gain, disordered puberty and poor neurocognitive development in children with long term detrimental outcomes.

Indexed as

HypothyroidismThyroxineChildHumansPubertyThyroxineGrowthHypothyroidismPubertyThyroid

Identifiers

PMID37926822
PMCPMC10626719

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.