Evidence map›Paper›PMID 37926623›Full record

ArticleHormones and behavior2024

Acute nicotine intake increases feeding behavior through decreasing glucagon signaling in dependent male and female rats.

Kokila Shankar, Jarryd Ramborger, Sélène Bonnet-Zahedi, Lieselot L G Carrette, Olivier George

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Hormones and behavior, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 2 countries.

Kokila ShankarDepartment of Psychiatry, University of California San Diego, La Jolla, CA 92093, USA; The Scripps Research Institute, La Jolla, CA 92037, USA.
Jarryd RamborgerDepartment of Psychiatry, University of California San Diego, La Jolla, CA 92093, USA.
Sélène Bonnet-ZahediDepartment of Psychiatry, University of California San Diego, La Jolla, CA 92093, USA; Institut de Neurosciences de la Timone, Aix-Marseille Université, Marseille 13005, France.
Lieselot L G CarretteDepartment of Psychiatry, University of California San Diego, La Jolla, CA 92093, USA.
Olivier GeorgeDepartment of Psychiatry, University of California San Diego, La Jolla, CA 92093, USA. Electronic address: olgeorge@health.ucsd.edu.
University of California, San Diego · US

Funding

Single-cell whole brain imaging of nicotine intoxication, dependence, and abstinenceR21DA057694 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GEORGE, OLIVIER · 2023 to 2024
$435k
NIDA NIH HHS R21 DA057694
6 · The paper itself

Abstract

Chronic use of nicotine is known to dysregulate metabolic signaling through altering circulating levels of feeding-related hormones, contributing to the onset of disorders like type 2 diabetes. However, little is known about the acute effects of nicotine on hormonal signaling. We previously identified an acute increase in food intake following acute nicotine, and we sought to determine whether this behavior was due to a change in hormone levels. We first identified that acute nicotine injection produces an increase in feeding behavior in dependent rats, but not nondependent rats. We confirmed that chronic nicotine use increases circulating levels of insulin, leptin, and ghrelin, and these correlate with rats' body weight and food intake. Acute nicotine injection in dependent animals decreased circulating GLP-1 and glucagon levels, and administration of glucagon prior to acute nicotine injection prevented the acute increase in feeding behavior. Thus, acute nicotine injection increases feeding behavior in dependent rats by decreasing glucagon signaling.

Indexed as

Diabetes Mellitus, Type 2GlucagonAnimalsEatingFeeding BehaviorFemaleGhrelinGlucagon-Like Peptide 1MaleNicotineRatsGhrelinGlucagonGlucagon-Like Peptide 1NicotineAddictionGhrelinGLP-1GlucagonInsulinLeptinMealNicotine dependenceRodent

Identifiers

PMID37926623
PMCPMC11384237
OpenAlexW4388342527

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.