Evidence map›Paper›PMID 37926124›Full record

ReviewThe Journal of allergy and clinical immunology2024

Engineering nanoparticle therapeutics for food allergy.

Laila M Rad, Gabriel Arellano, Joseph R Podojil, Jessica J O'Konek, Lonnie D Shea, Stephen D Miller

Open access · greenAbstract readReview
In one paragraph

Review in The Journal of allergy and clinical immunology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
4.6field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 19 citations in OpenAlex.

  1. Review
  2. Next-Generation Allergen-Specific Immunotherapy for Food Allergy.Clinical reviews in allergy & immunology · 2025
    Review
  3. Review
  4. Review
  5. Article
  6. Review
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 2 countries.

Laila M RadDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, Mich.
Gabriel ArellanoDepartment of Microbiology-Immunology, Northwestern University, Chicago, Ill; Center for Human Immunology, Northwestern University, Chicago, Ill.
Joseph R PodojilDepartment of Microbiology-Immunology, Northwestern University, Chicago, Ill; Center for Human Immunology, Northwestern University, Chicago, Ill; Cour Pharmaceutical Development Company, Skokie, Ill.
Jessica J O'KonekMary H. Weiser Food Allergy Center, Michigan Medicine, Ann Arbor, Mich. Electronic address: jjoz@umich.edu.
Lonnie D SheaDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, Mich. Electronic address: ldshea@umich.edu.
Stephen D MillerDepartment of Microbiology-Immunology, Northwestern University, Chicago, Ill; Center for Human Immunology, Northwestern University, Chicago, Ill. Electronic address: s-d-miller@northwestern.edu.
Northwestern University · PHUniversity of Michigan–Ann Arbor · USMichigan Medicine · USNorthwestern University · US

Funding

NPs disguised as apoptotic debris for immune toleranceR01AI155678 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI STEPHEN D MILLER, Lonnie D Shea · 2020 to 2026
$4.7M
Nanoparticle-mediated reprogramming of circulating monocytes and neutrophils to decrease inflammation-mediated damage after traumaR01AI148076 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ANDERSON, AILEEN J, SHEA, LONNIE D · 2019 to 2023
$3.4M
DEVELOPMENT OF NANOVAX TM (OIL IN WATER NANOEMULSION ADJUVANT) FORMULATED ALLERGENS AS INTRANASAL IMMUNOTHERAPEUTIC VACCINES FOR PEANUT ALLERGY.75N93019C00035 · NIAID · BLUEWILLOW BIOLOGICS, INC. · PI FATTOM, ALI I. · 2019 to 2023
$3.3M
Mechanistic evaluation of Th2-polarizing bystander effects of early life immunization with alumR21AI155944 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI O'KONEK, JESSICA JANE · 2021 to 2022
$429k
NIAID NIH HHS 75N93019C00035NIAID NIH HHS R01 AI148076NIAID NIH HHS R01 AI155678NIAID NIH HHS R21 AI155944
6 · The paper itself

Abstract

Food allergy is a growing public health issue among children and adults that can lead to life-threatening anaphylaxis following allergen exposure. The criterion standard for disease management includes food avoidance and emergency epinephrine administration because current allergen-specific immunotherapy treatments are limited by adverse events and unsustained desensitization. A promising approach to remedy these shortcomings is the use of nanoparticle-based therapies that disrupt disease-driving immune mechanisms and induce more sustained tolerogenic immune pathways. The pathophysiology of food allergy includes multifaceted interactions between effector immune cells, including lymphocytes, antigen-presenting cells, mast cells, and basophils, mainly characterized by a T

Indexed as

Food HypersensitivityNanoparticlesAdultAllergensChildDesensitization, ImmunologicFoodHumansAllergensallergen-specific immunotherapydesensitizationFood allergyliposomesnanoemulsionnanoparticlestolerance

Identifiers

PMID37926124
PMCPMC10939913
OpenAlexW4388343790

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.