Trial reportTrials2023
Lung UltrasouNd Guided surfactant therapy in preterm infants: an international multicenter randomized control trial (LUNG study).
Trial report in Trials, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05198375 (Lung UltrasouNd Guided Surfactant Therapy in Preterm Infants), which is not on this map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Lung UltrasouNd Guided Surfactant Therapy in Preterm Infants: an International Multicentric Randomized Control Trial (LUNG Study)
Who cites it
14 citing papers in PubMed, 19 citations in OpenAlex.
- Expanded versus classical assessments for identifying mandate for lung ultrasound-guided surfactant therapy in preterm neonates (EXCLAIM-LUS): a retrospective comparative study.European journal of pediatrics · 2026Observational
- Lung Ultrasound-Guided Surfactant Therapy in Neonatal Pneumothorax and Pulmonary Hemorrhage: Pathophysiology, Diagnostic Ultrasonography, and Emerging Clinical Approaches.Children (Basel, Switzerland) · 2026Review
- Utilization of integrated lung ultrasound and targeted neonatal echocardiography in preterm infant follow-up: is it feasible? Assessing value and practical challenges.European journal of pediatrics · 2026Review
- Prospective, Non-Blinded, Randomized Controlled Trial of Pulmonary Surfactant Administration Guided by Lung Ultrasound in Preterm Infants with Gestational Age < 32 Weeks.Children (Basel, Switzerland) · 2025Article
- Serial lung ultrasound in predicting the need for surfactant and respiratory course in preterm infants-multicentre observational study (SLURP).European journal of pediatrics · 2025Observational
- Lung Ultrasound in Critical Care: A Narrative Review.Diagnostics (Basel, Switzerland) · 2025Review
- Evaluation of the Predictive Value of Lung Ultrasound Scoring Systems in Assessing Bronchopulmonary Dysplasia Severity Among Preterm Infants: Correlation Analysis with Therapeutic Strategies and Clinical Management Protocols.International journal of general medicine · 2025Article
- Spectral analysis of gastric aspirates obtained shortly after birth predicts the need for prolonged respiratory support in neonates in a development cohort.Frontiers in pediatrics · 2025Article
- Lung ultrasound imaging can effectively monitor and guide treatment with pulmonary surfactant for preterm infants of pulmonary consolidation: a prospective observational cohort study.Frontiers in pediatrics · 2025Article
- Lung Ultrasound in Neonatal Respiratory Distress Syndrome: A Narrative Review of the Last 10 Years.Diagnostics (Basel, Switzerland) · 2024Review
- Review
- Lung ultrasound for prediction of surfactant requirement in Indian preterm neonates: a diagnostic accuracy study.European journal of pediatrics · 2024Article
- Predictors of CPAP failure after less-invasive surfactant administration in preterm infants.Frontiers in pediatrics · 2024Article
- Prospective, non-blinded, randomized controlled trial on early administration of pulmonary surfactant guided by lung ultrasound scores in very preterm infants: study protocol.Frontiers in pediatrics · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
40 authors at 20 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe management of respiratory distress syndrome (RDS) in premature newborns is based on different types of non-invasive respiratory support and on surfactant replacement therapy (SRT) to avoid mechanical ventilation as it may eventually result in lung damage. European guidelines currently recommend SRT only when the fraction of inspired oxygen (FiO METHODS/
designIn this study, 668 spontaneously-breathing preterm infants, born at 25 DISCUSSION: Based on previous published studies, it seems that LUS may decrease the time to administer surfactant therapy. It is known that early surfactant administration decreases BPD and mortality. Therefore, there is rationale for hypothesizing a reduction in BPD or death in the group of patients in which the decision to administer exogenous surfactant is based on lung ultrasound scores.
trial registrationClinicalTrials.gov identifier NCT05198375 . Registered on 20 January 2022.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.