Evidence map›Paper›PMID 37925493›Full record

ArticleNPJ biofilms and microbiomes2023

Inulin-enriched Megamonas funiformis ameliorates metabolic dysfunction-associated fatty liver disease by producing propionic acid.

Xinyue Yang, Meihong Zhang, Yan Liu, Fuxiao Wei, Xin Li, Yuqing Feng, Xiaolu Jin, Dan Liu, Yuming Guo, Yongfei Hu

Erratum issuedOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NPJ biofilms and microbiomes, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 52 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
52citing papers in PubMed, 1 pooled it
11.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

52 citing papers in PubMed, 1 synthesis or guideline pooled it, 72 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Metagenomic Insights into Gut Microbiota Alterations FollowingInternational journal of molecular sciences · 2026
    Article
  13. Review
  14. Review
  15. Review
  16. Article
  17. Article
  18. Effects of inactivatedAnimal nutrition (Zhongguo xu mu shou yi xue hui) · 2026
    Article
  19. Review
  20. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Xinyue YangState Key Laboratory of Animal Nutrition and Feeding, College of Animal Science and Technology, China Agricultural University, 100193, Beijing, China.
Meihong ZhangState Key Laboratory of Animal Nutrition and Feeding, College of Animal Science and Technology, China Agricultural University, 100193, Beijing, China.
Yan LiuState Key Laboratory of Animal Nutrition and Feeding, College of Animal Science and Technology, China Agricultural University, 100193, Beijing, China.
Fuxiao WeiState Key Laboratory of Animal Nutrition and Feeding, College of Animal Science and Technology, China Agricultural University, 100193, Beijing, China.
Xin LiState Key Laboratory of Animal Nutrition and Feeding, College of Animal Science and Technology, China Agricultural University, 100193, Beijing, China.
Yuqing FengState Key Laboratory of Animal Nutrition and Feeding, College of Animal Science and Technology, China Agricultural University, 100193, Beijing, China.
Xiaolu JinState Key Laboratory of Animal Nutrition and Feeding, College of Animal Science and Technology, China Agricultural University, 100193, Beijing, China.
Dan LiuState Key Laboratory of Animal Nutrition and Feeding, College of Animal Science and Technology, China Agricultural University, 100193, Beijing, China.
Yuming GuoState Key Laboratory of Animal Nutrition and Feeding, College of Animal Science and Technology, China Agricultural University, 100193, Beijing, China.
Yongfei HuState Key Laboratory of Animal Nutrition and Feeding, College of Animal Science and Technology, China Agricultural University, 100193, Beijing, China. huyongfei@cau.edu.cn.ORCID 0000-0002-2158-6018
China Agricultural University · CN

Funding

National Natural Science Foundation of China (National Science Foundation of China) 32372824Natural Science Foundation of Beijing Municipality (Beijing Natural Science Foundation) 6222032
6 · The paper itself

Abstract

Accumulated evidence supports the beneficial role of inulin in alleviating metabolic dysfunction-associated fatty liver disease (MAFLD) by modulating gut microbiota. However, the underlying mechanisms are not fully understood. Here we used high-fat diet (HFD)-induced laying hen model of MAFLD to investigate the effect of inulin on ameliorating MAFLD and found that the inulin-enriched Megamonas genus was inversely correlated with hepatic steatosis-related parameters. Oral administration of a newly isolated commensal bacterium by culturomics, M. funiformis CML154, to HFD-fed hens and mice ameliorated MAFLD, changed liver gene expression profiles, and increased intestinal propionate concentration. Further evidence demonstrated that the anti-MAFLD effect of M. funiformis CML154 is attributed to propionate-mediated activation of the APN-AMPK-PPARα signaling pathway, thereby inhibiting fatty acid de novo synthesis and promoting β-oxidation. These findings establish the causal relationships among inulin, M. funiformis, and MAFLD, and suggest that M. funiformis CML154 is a probiotic candidate for preventative or therapeutic intervention of MAFLD.

Indexed as

Non-alcoholic Fatty Liver DiseasePropionatesAnimalsBacillotaChickensFemaleInulinMiceInulinPropionatespropionic acid

Identifiers

PMID37925493
PMCPMC10625582
OpenAlexW4388341874

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.