ArticleNature communications2023
Poor sleep and shift work associate with increased blood pressure and inflammation in UK Biobank participants.
Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 74 papers, 1 of them a synthesis that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
74 citing papers in PubMed, 1 synthesis or guideline pooled it, 101 citations in OpenAlex.
- Association between night shift work and cardiovascular disease: a systematic review and dose-response meta-analysis.Frontiers in public health · 2025Pooled it
- Poor sleep quality and its association patterns with eating disorders, body composition and physical activity among university students in Douala-Cameroon.IBRO neuroscience reports · 2026Article
- Sleep quality partially mediates the association between remnant cholesterol inflammatory index and depressive symptoms: multi-cohort analysis from cross-sectional and longitudinal cohorts.European archives of psychiatry and clinical neuroscience · 2026Article
- PER1-related inflammatory signaling links night shift exposure to lower lung function in coal miners.iScience · 2026Article
- Association Between Sleep Debt and Mental Well-Being in School-Aged Children and Adolescents in China: A Multi-Province, Cross-Sectional, Observational Study.Healthcare (Basel, Switzerland) · 2026Article
- Association between weekend catch-up sleep and stroke among US adults: A cross-sectional analysis of NHANES.Medicine · 2026Article
- Genetic evidence linking circadian rhythm genes and hypertension: A two-sample Mendelian randomization study.The Journal of international medical research · 2026Article
- Unlocking the potential of circadian biology for cardiovascular health.Physiological reviews · 2026Review
- Night shift work and the acceleration of chronic kidney disease onset: dose-response relationships, interactions with cardiometabolic genetic risk, and metabolomic mediators.Scandinavian journal of work, environment & health · 2026Article
- Centralized Review of Alzheimer's Disease and Related Dementias Biomedical Repositories and Computational Methods.Bioengineering (Basel, Switzerland) · 2026Review
- Article
- Investigating the Risk of Obesity in European Night Shift Workers: A Study Protocol for Cross-Sectional and Mechanistic Studies in the SHIFT2HEALTH Project.Obesity facts · 2026Article
- Prospective association between circadian syndrome and incident chronic lung disease in the CHARLS and ELSA cohorts.Scientific reports · 2026Article
- The mediating effect of immune-inflammatory indices in shift work and hypertension: a cohort study in China.Scandinavian journal of work, environment & health · 2026Article
- Joint Associations of Sleep Patterns and Genetic Susceptibility With Dynamic Transitions of Chronic Obstructive Pulmonary Disease and Coronary Heart Disease and the Mediating Role of Inflammatory Biomarkers and Metabolites.Journal of the American Heart Association · 2026Article
- A newly developed circadian imbalance index (CII) and risk of cardiovascular-kidney-metabolic disease in the UK biobank.European journal of epidemiology · 2026Article
- Exploring the relationship between sleep patterns and cardio-renal-metabolic multimorbidity in Chinese and European populations.Journal of health, population, and nutrition · 2026Article
- Sleep timing irregularity in midlife: association with incident major adverse cardiac events and cardiovascular disease mortality over a 10-year follow-up.BMC cardiovascular disorders · 2026Article
- Association Between Healthy Lifestyle Habits and Intrinsic Capacity Among Community-Dwelling Older Adults in Singapore.Nutrients · 2026Article
- Diurnal variation in neurovascular coupling and the impact of sleep quality: a UK Biobank study.Sleep · 2026Article
14 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Disrupted circadian rhythms have been linked to an increased risk of hypertension and cardiovascular disease. However, many studies show inconsistent findings and are not sufficiently powered for targeted subgroup analyses. Using the UK Biobank cohort, we evaluate the association between circadian rhythm-disrupting behaviours, blood pressure (SBP, DBP) and inflammatory markers in >350,000 adults with European white British ancestry. The independent U-shaped relationship between sleep length and SBP/DBP is most prominent with a low inflammatory status. Poor sleep quality and permanent night shift work are also positively associated with SBP/DBP. Although fully adjusting for BMI in the linear regression model attenuated effect sizes, these associations remain significant. Two-sample Mendelian Randomisation (MR) analyses support a potential causal effect of long sleep, short sleep, chronotype, daytime napping and sleep duration on SBP/DBP. Thus, in the current study, we present a positive association between circadian rhythm-disrupting behaviours and SBP/DBP regulation in males and females that is largely independent of age.
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