Evidence map›Paper›PMID 37925427›Full record

ArticleBMC neurology2023

Complete loss of E-cadherin expression in a rare case of metastatic malignant meningioma: a case report.

Dominik Lisowski, Philipp E Hartrampf, Natalie Hasenauer, Vera Nickl, Camelia-Maria Monoranu, Jörg Tamihardja

Open access · goldAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC neurology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Dominik LisowskiDepartment of Radiation Oncology, University Hospital Würzburg, Josef-Schneider-Str. 11, 97080, Würzburg, Germany, Germany. lisowski_d@ukw.de.ORCID http://orcid.org/0000-0001-8771-2155
Philipp E HartrampfDepartment of Nuclear Medicine, University Hospital Würzburg, Würzburg, Germany.
Natalie HasenauerDepartment of Nuclear Medicine, University Hospital Würzburg, Würzburg, Germany.
Vera NicklDepartment of Neurosurgery, University Hospital Würzburg, Würzburg, Germany.
Camelia-Maria MonoranuDepartment of Neuropathology, Institute of Pathology, University of Würzburg, Würzburg, Germany.
Jörg TamihardjaDepartment of Radiation Oncology, University Hospital Würzburg, Josef-Schneider-Str. 11, 97080, Würzburg, Germany, Germany.
Universitätsklinikum Würzburg · DEUniversity of Würzburg · DE

Funding

Interdisziplinäres Zentrum für Klinische Forschung, Universitätsklinikum Würzburg Z-02/85
6 · The paper itself

Abstract

backgroundHematogenous tumor spread of malignant meningiomas occurs very rarely but is associated with very poor prognosis. CASE PRESENTATION: We report an unusual case of a patient with a malignant meningioma who developed multiple metastases in bones, lungs and liver after initial complete resection of the primary tumor. After partial hepatic resection, specimens were histologically analyzed, and a complete loss of E-cadherin adhesion molecules was found. No oncogenic target mutations were found. The patient received a combination of conventional radiotherapy and peptide receptor radionuclide therapy (PRRT). Due to aggressive tumor behavior and rapid spread of metastases, the patient deceased after initiation of treatment.

conclusionsE-cadherin downregulation is associated with a higher probability of tumor invasion and distant metastasis formation in malignant meningioma. Up to now, the efficacy of systemic therapy, including PRRT, is very limited in malignant meningioma patients.

Indexed as

Meningeal NeoplasmsMeningiomaAntigens, CDCadherinsHumansPrognosisAntigens, CDCadherinsCDH1 protein, humanBeta-cateninE-cadherinMeningiomaPeptide receptor radionuclide therapy (PRRT)Radiotherapy

Identifiers

PMID37925427
PMCPMC10625181
OpenAlexW4388345279

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.