Evidence map›Paper›PMID 37925426›Full record

ArticleBMC women's health2023

Thyroid hormones and ovarian reserve: a comprehensive study of women seeking infertility care.

Muge Halici, Mustafa Ege Seker, Irem Yagmur Gebedek, Merve Nida Gokbak, Abdurrahman Furkan Cetisli, Ahmet Berkan Ciftci, Emine Konac, Sule Yildirim Kopuk, Bulent Tiras, Yigit Cakiroglu

Abstract read
In one paragraph

Article in BMC women's health, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Muge HaliciSchool of Medicine, Acibadem Mehmet Ali Aydinlar University, Atasehir, Istanbul, 34752, Turkey. mugehalici@gmail.com.ORCID 0000-0002-0688-3217
Mustafa Ege SekerSchool of Medicine, Acibadem Mehmet Ali Aydinlar University, Atasehir, Istanbul, 34752, Turkey.ORCID 0000-0001-7664-5786
Irem Yagmur GebedekSchool of Medicine, Acibadem Mehmet Ali Aydinlar University, Atasehir, Istanbul, 34752, Turkey.ORCID 0000-0003-2282-1064
Merve Nida GokbakSchool of Medicine, Acibadem Mehmet Ali Aydinlar University, Atasehir, Istanbul, 34752, Turkey.ORCID 0000-0002-9220-9455
Abdurrahman Furkan CetisliSchool of Medicine, Acibadem Mehmet Ali Aydinlar University, Atasehir, Istanbul, 34752, Turkey.ORCID 0000-0001-8962-4909
Ahmet Berkan CiftciSchool of Medicine, Acibadem Mehmet Ali Aydinlar University, Atasehir, Istanbul, 34752, Turkey.ORCID 0000-0003-1039-2995
Emine KonacSchool of Medicine, Acibadem Mehmet Ali Aydinlar University, Atasehir, Istanbul, 34752, Turkey.ORCID 0000-0002-7220-5596
Sule Yildirim KopukAssisted Reproductive Technologies Unit, Acibadem Maslak Hospital, Sariyer, Istanbul, 34398, Turkey.ORCID 0000-0002-5020-8323
Bulent TirasSchool of Medicine, Acibadem Mehmet Ali Aydinlar University, Atasehir, Istanbul, 34752, Turkey.ORCID 0000-0003-2297-3332
Yigit CakirogluSchool of Medicine, Acibadem Mehmet Ali Aydinlar University, Atasehir, Istanbul, 34752, Turkey.ORCID 0000-0002-2779-8599

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundOvarian reserve is the number of oocytes remaining in the ovary and is one of the most important aspects of a woman's reproductive potential. Research on the association between thyroid dysfunction and ovarian reserve has yielded controversial results. In our study, we aimed to investigate the relationship between thyroid-stimulating hormone (TSH) levels and ovarian reserve markers.

methodsFrom 1443 women seeking infertility care, the data of 1396 women aged between 20-45 years old who had a body mass index between 18-30 kg/m

resultsMedian age, follicle-stimulating hormone (FSH), AMH, and TSH levels were 36.79 years, 9.55 IU/L, 3.57 pmol/L, and 1.80 mIU/L, respectively. Differences between TSH groups were statistically significant in terms of AMH level, antral follicle count (AFC), and age (p = 0.007 and p = 0.038, respectively). A generalized linear regression model could not explain age-matched TSH levels concerning AMH levels (p > 0.05). TSH levels were utilized in polynomial regression models of AMH, and the 2

conclusionsOur study shows a correlation between TSH and AMH values in a population of infertile women. Our results are as follows: a TSH value of 2.88 mIU/L yields the highest AMH result. It was also found that AMH and AFC were positively correlated, while AMH and FSH were negatively correlated.

Indexed as

Infertility, FemaleOvarian ReserveAdultAnti-Mullerian HormoneFemaleFollicle Stimulating HormoneHumansMiddle AgedOvarian FollicleRetrospective StudiesThyroid HormonesThyrotropinYoung AdultAnti-Mullerian HormoneFollicle Stimulating HormoneThyroid HormonesThyrotropinAFCAMHFSHInfertilityOvarian reserveTSH

Identifiers

PMID37925426
PMCPMC10625203

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.