Evidence map›Paper›PMID 37924862›Full record

ArticleJournal of molecular biology2023

Solution Structure of Poly(UG) RNA.

Cristian A Escobar, Riley J Petersen, Marco Tonelli, Lixin Fan, Katherine A Henzler-Wildman, Samuel E Butcher

Open access · greenAbstract read
In one paragraph

Article in Journal of molecular biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Perspective - RNA Dynamics Today and Tomorrow.Journal of molecular biology · 2026
    Review
  4. Article
  5. Article
  6. TDP-43 controls RNA structure through high affinity lattice interactions.bioRxiv : the preprint server for biology · 2025
    Article
  7. Sequence and ionic requirements of pUG fold quadruplexes.bioRxiv : the preprint server for biology · 2025
    Article
  8. Article
  9. Article
  10. Article
  11. A left-handed RNA quadruplex directs gene silencing.Trends in biochemical sciences · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Cristian A EscobarDepartment of Biochemistry, University of Wisconsin-Madison, Madison, WI, USA.
Riley J PetersenDepartment of Biochemistry, University of Wisconsin-Madison, Madison, WI, USA.
Marco TonelliDepartment of Biochemistry, University of Wisconsin-Madison, Madison, WI, USA; National Magnetic Resonance Facility at Madison, University of Wisconsin-Madison, Madison, WI, USA.
Lixin FanBasic Science Program, Frederick National Laboratory for Cancer Research, SAXS Core Facility of National Cancer Institute, Frederick, MD, USA.
Katherine A Henzler-WildmanDepartment of Biochemistry, University of Wisconsin-Madison, Madison, WI, USA; National Magnetic Resonance Facility at Madison, University of Wisconsin-Madison, Madison, WI, USA.
Samuel E ButcherDepartment of Biochemistry, University of Wisconsin-Madison, Madison, WI, USA; National Magnetic Resonance Facility at Madison, University of Wisconsin-Madison, Madison, WI, USA. Electronic address: sebutcher@wisc.edu.
University of Wisconsin–Madison · USFrederick National Laboratory for Cancer Research · US

Funding

WORK ORDER 126643 B539 EXPAND IC SUITE75N91019D00024 · NIAID · LEIDOS BIOMEDICAL RESEARCH, INC. · PI BRISCOE, LYNN · 2019 to 2025
$3932.6M
TRD3 NMRbox: Bayesian AnalyticsP41GM111135 · NIGMS · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI HOCH, JEFFREY C · 2015 to 2024
$14.0M
TR&D 3: TECHNOLOGY DEVELOPMENT FOR NMR STUDIES OF SMALL MOLECULES (METABOLOMICS, NATURAL PRODUCTS, METABOLITE-PROTEIN INTERACTIONS) pp.537-585 P41GM103399 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI BUTCHER, SAMUEL E · 2012 to 2019
$9.4M
Technologies for Solid-State NMR Data CollectionP41GM136463 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI WESTLER, WILLIAM MILO · 2021 to 2025
$6.4M
NMR User Program at NMRFAMR24GM141526 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI Katherine Anne Henzler-Wildman · 2021 to 2026
$6.4M
Biophysical investigations of RNA complexes essential for gene expressionR35GM118131 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI Samuel E Butcher · 2016 to 2026
$5.1M
NCI NIH HHS 75N91019D00024NIGMS NIH HHS P41 GM103399NIGMS NIH HHS P41 GM111135NIGMS NIH HHS P41 GM136463NIGMS NIH HHS R24 GM141526NIGMS NIH HHS R35 GM118131
6 · The paper itself

Abstract

Poly(UG) or "pUG" RNAs are UG or GU dinucleotide repeat sequences which are highly abundant in eukaryotes. Post-transcriptional addition of pUGs to RNA 3' ends marks mRNAs as vectors for gene silencing in C. elegans. We previously determined the crystal structure of pUG RNA bound to the ligand N-methyl mesoporphyrin IX (NMM), but the structure of free pUG RNA is unknown. Here we report the solution structure of the free pUG RNA (GU)

Indexed as

Poly GPoly URNAAnimalsCaenorhabditis elegansCrystallography, X-RayLigandsModels, MolecularNucleic Acid ConformationScattering, Small AngleX-Ray DiffractionLigandsPoly GPoly Upoly(U-G)RNANMRpoly(UG)QuadruplexRNASAXS

Identifiers

PMID37924862
PMCPMC10841838
OpenAlexW4388209056

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.