ArticleCurrent biology : CB2023
Odor representations from the two nostrils are temporally segregated in human piriform cortex.
Article in Current biology : CB, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 12 citations in OpenAlex.
- Theta oscillations are an organizational unit of odor processing in the olfactory bulb.Science advances · 2026Article
- Behavioral Relevance of Early Neural Coding of Low-Level Odor Features in Humans.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Cross-Sectional and Longitudinal Associations Between Olfaction and White-Matter Integrity Across the Lifespan.Human brain mapping · 2025Article
- 3D spatial transcriptomics reveals the molecular structure of input and output pathways in the mouse olfactory bulb.bioRxiv : the preprint server for biology · 2025Article
- Article
- How do mammals convert dynamic odor information into neural maps for landscape navigation?PLoS biology · 2024Article
- Imbalance inInternational journal of molecular sciences · 2024Article
- Monorhinal and birhinal odor processing in humans: an fMRI investigation.Chemical senses · 2024Article
- Article
- One nose but two nostrils: Learn to align with sparse connections between two olfactory cortices.PRX lifeArticle
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7 authors at 3 institutions in 1 country.
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Abstract
The human olfactory system has two discrete channels of sensory input, arising from olfactory epithelia housed in the left and right nostrils. Here, we asked whether the primary olfactory cortex (piriform cortex [PC]) encodes odor information arising from the two nostrils as integrated or distinct stimuli. We recorded intracranial electroencephalogram (iEEG) signals directly from PC while human subjects participated in an odor identification task where odors were delivered to the left, right, or both nostrils. We analyzed the time course of odor identity coding using machine-learning approaches and found that uni-nostril odor inputs to the ipsilateral nostril are encoded ∼480-ms faster than odor inputs to the contralateral nostril on average. During naturalistic bi-nostril odor sampling, odor information emerged in two temporally segregated epochs, with the first epoch corresponding to the ipsilateral and the second epoch corresponding to the contralateral odor representations. These findings reveal that PC maintains distinct representations of odor input from each nostril through temporal segregation, highlighting an olfactory coding scheme at the cortical level that can parse odor information across nostrils within the course of a single inhalation.
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