ArticleJournal of cancer survivorship : research and practice2025
Depressive symptom trajectories in older breast cancer survivors: the Thinking and Living with Cancer Study.
Article in Journal of cancer survivorship : research and practice, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 12 citations in OpenAlex.
- Article
- The role of social engagement and support in the association between combined caregiver-cancer survivor status and depressive symptoms.The Gerontologist · 2026Article
- Intrinsic capacity in community-dwelling older adults and cancer survivors: a comparative study.European geriatric medicine · 2025Article
- Emotional Functioning as a Dimension of Quality of Life in Breast Cancer Survivors: A Systematic Review and Meta-Analysis.Cancers · 2025Review
- Acute Change in Perceived Cognitive Performance Across Different Age Groups Following First Chemotherapy Infusion in Female Patients With Breast Cancer.Psycho-oncology · 2025Article
- Trajectories and predictors of anxiety and depression among older cancer survivors: a nationally representative cohort study.Journal of cancer survivorship : research and practice · 2025Article
- Early Cancer Survivorship Distress Trajectories Associated With Socioeconomic Status and Age: Findings From a Multicenter Prospective Study.Cancer medicine · 2025Article
- Nonregular Physical Activity and Handgrip Strength as Indicators of Fatigue and Psychological Distress in Cancer Survivors.Current oncology (Toronto, Ont.) · 2025Article
- Anxiety and Depression Trajectories in Young Adults Up to 5 Years After Being Diagnosed With Cancer.Cancer medicine · 2025Article
- Effects of a Multimodal Program on Frailty Syndrome and Psychological Alterations in Breast Cancer Women Treated with Aromatase Inhibitors.Clinics and practice · 2025Article
- Are breast cancer patients with low distress at diagnosis at risk of psychological symptoms later in their disease trajectory? Considerations for when to screen for distress.Acta oncologica (Stockholm, Sweden) · 2025Article
- Interpersonal emotion regulation and mental health among cancer survivors: A systematic review.International journal of clinical and health psychology : IJCHPArticle
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Authors and funding
25 authors at 13 institutions in 1 country.
Funding
Abstract
purposeTo identify trajectories of depressive symptoms in older breast cancer survivors and demographic, psychosocial, physical health, and cancer-related predictors of these trajectories.
methodsRecently diagnosed nonmetastatic breast cancer survivors (n = 272), ages 60-98 years, were evaluated for depressive symptoms (Center for Epidemiological Studies Depression Scale, CES-D; scores ≥16 suggestive of clinically significant depressive symptoms). CES-D scores were analyzed in growth-mixture models to determine depression trajectories from baseline (post-surgery, pre-systemic therapy) through 3-year annual follow-up. Multivariable, multinomial logistic regression was used to identify baseline predictors of depression trajectories.
resultsSurvivors had three distinct trajectories: stable (84.6%), emerging depressive symptoms (10.3%), and recovery from high depressive symptoms at baseline that improved slowly over time (5.1%). Compared to stable survivors, those in the emerging (OR = 1.16; 95% CI = 1.08-1.23) or recovery (OR = 1.26; 95% CI = 1.15-1.38) groups reported greater baseline anxiety. Greater baseline deficit accumulation (frailty composite measure) was associated with emerging depressive symptoms (OR = 3.71; 95% CI = 1.90-7.26). Less social support at baseline (OR = 0.38; 95% CI = 0.15-0.99), but greater improvement in emotional (F = 4.13; p = 0.0006) and tangible (F = 2.86; p = 0.01) social support over time, was associated with recovery from depressive symptoms.
conclusionsFifteen percent of older breast cancer survivors experienced emerging or recovery depressive symptom trajectories. Baseline anxiety, deficit accumulation, and lower social support were associated with worse outcomes. IMPLICATIONS FOR CANCER SURVIVORS: Our results emphasize the importance of depression screening throughout the course of cancer care to facilitate early intervention. Factors associated with depressive symptoms, including lower levels of social support proximal to diagnosis, could serve as intervention levers.
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