ArticleEuropean journal of nuclear medicine and molecular imaging2024
STING-targeted PET tracer for early assessment of tumor immunogenicity in colorectal cancer after chemotherapy.
Article in European journal of nuclear medicine and molecular imaging, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 12 citations in OpenAlex.
- Therapeutic targeting of the cGAS-STING pathway in human disease.The Journal of clinical investigation · 2026Review
- Development of STING probes and visualization of STING in multiple tumor types.European journal of nuclear medicine and molecular imaging · 2025Article
- SYL3C Aptamer-DNA Tetrahedra Conjugates Enable Near-Infrared Fluorescent Imaging of Colorectal Cancer.International journal of nanomedicine · 2025Article
- Recent advances in nanoadjuvant-triggered STING activation for enhanced cancer immunotherapy.Heliyon · 2024Review
- STING-targeted PET imaging: unveiling tumor immunogenicity post-chemotherapy in colorectal cancer.European journal of nuclear medicine and molecular imaging · 2024Article
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
purposeTo optimize chemotherapy regimens and improve the effectiveness of chemotherapy combined with immunotherapy, a PET tracer specifically targeting the stimulator of interferon genes (STING), denoted as [
methodsThe toluene sulfonate precursor was labeled with
resultsPET imaging of CRC mice exhibited notably enhanced tumor uptake in the early phase of chemotherapy with treatment with OXA (3.09 ± 0.25%ID/g) and CDDP (4.01 ± 0.18%ID/g), especially in the CDDP group. The PET-derived tumor uptake values have strong correlations with STING immunohistochemical score. Flow cytometry showed both agents led to DCs and macrophages infiltration in tumors. Compared with OXA, CDDP treatment recruits more DCs and macrophages in CRC tumors. Both CDDP-LD and CDDP-MD treatment elevated uptake in CRC tumors, especially in CDDP-MD group. Immunohistochemistry and flow cytometry confirmed CDDP-MD treatment recruits more DCs and macrophages than CDDP-LD treatment.
conclusionOverall, the STING-targeted tracer-[
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Registered trials
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