Evidence map›Paper›PMID 37924310›Full record

ArticleProtein science : a publication of the Protein Society2023

Enhancing thermal stability in the CH

Kosuke Oyama, Makoto Nakakido, Takatoshi Ohkuri, Hitomi Nakamura, Kouhei Tsumoto, Tadashi Ueda

Abstract read
In one paragraph

Article in Protein science : a publication of the Protein Society, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Enhancing thermal stability in the CHProtein science : a publication of the Protein Society · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Kosuke OyamaGraduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan.ORCID 0009-0004-7821-5236
Makoto NakakidoGraduate School of Engineering, The University of Tokyo, Tokyo, Japan.ORCID 0000-0003-0328-9914
Takatoshi OhkuriFaculty of Pharmaceutical Sciences, Sojo University, Kumamoto, Japan.ORCID 0000-0003-0685-3330
Hitomi NakamuraFaculty of Pharmaceutical Sciences, Sojo University, Kumamoto, Japan.
Kouhei TsumotoGraduate School of Engineering, The University of Tokyo, Tokyo, Japan.
Tadashi UedaGraduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan.

Funding

Academic Challenge 2020 in Robert T. Huang Entrepreneurship Center of Kyushu UniversityJSPS KAKENHI 15K15184JST SPRING JPMJSP2136
6 · The paper itself

Abstract

Protein aggregations decrease production yields and impair the efficacy of therapeutics. The CH

Indexed as

SaccharomycetalesDisulfidesHumansImmunoglobulin GPichiaProtein DomainsDisulfidesImmunoglobulin GaggregationCH2 domaindisulfide bondIgGprotein stabilization

Identifiers

PMID37924310
PMCPMC10680342

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.