Evidence map›Paper›PMID 37924146›Full record

ArticleMolecular brain2023

Chronic pregabalin treatment protects against spreading depolarization and alters hippocampal synaptic characteristics in a model of familial hemiplegic migraine-type 1.

Stuart M Cain, Sascha R A Alles, Ray Gopaul, Louis-Philippe Bernier, Andrew C Yung, Andrew Bauman, Yi Yang, Glen B Baker, Piotr Kozlowski, Brian A MacVicar and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular brain, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Stuart M Cain *Michael Smith Laboratories, University of British Columbia, 219-2185 East Mall, Vancouver, BC, V6T 1Z4, Canada.
Sascha R A Alles *Michael Smith Laboratories, University of British Columbia, 219-2185 East Mall, Vancouver, BC, V6T 1Z4, Canada.
Ray GopaulMichael Smith Laboratories, University of British Columbia, 219-2185 East Mall, Vancouver, BC, V6T 1Z4, Canada.
Louis-Philippe BernierDjavad Mowafaghian Center for Brain Health, University of British Columbia, Vancouver, Canada.
Andrew C YungUBC MRI Research Facility, University of British Columbia, Vancouver, Canada.
Andrew BaumanUBC MRI Research Facility, University of British Columbia, Vancouver, Canada.
Yi YangMichael Smith Laboratories, University of British Columbia, 219-2185 East Mall, Vancouver, BC, V6T 1Z4, Canada.
Glen B BakerNeurochemical Research Unit, Department of Psychiatry, University of Alberta, Edmonton, Canada.
Piotr KozlowskiUBC MRI Research Facility, University of British Columbia, Vancouver, Canada.
Brian A MacVicarDjavad Mowafaghian Center for Brain Health, University of British Columbia, Vancouver, Canada.
Terrance P SnutchMichael Smith Laboratories, University of British Columbia, 219-2185 East Mall, Vancouver, BC, V6T 1Z4, Canada. snutch@msl.ubc.ca.ORCID 0000-0001-5182-1296
University of British Columbia · CAUniversity of Alberta · CAUniversity of British Columbia Hospital · CA

Funding

Neuroimmune mechanisms of a humanized CCK-B receptor scFv as therapy for chronic pain patientsUG3NS123958 · NINDS · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI ALLES, SASCHA R, WESTLUND-HIGH, KARIN N. · 2021 to 2022
$1.1M
NINDS NIH HHS 1UG3NS123958-01NINDS NIH HHS UG3 NS123958
6 · The paper itself

Abstract

Familial hemiplegic migraine type-1 (FHM-1) is a form of migraine with aura caused by mutations in the P/Q-type (Cav2.1) voltage-gated calcium channel. Pregabalin, used clinically in the treatment of chronic pain and epilepsy, inhibits P/Q-type calcium channel activity and recent studies suggest that it may have potential for the treatment of migraine. Spreading Depolarization (SD) is a neurophysiological phenomenon that can occur during migraine with aura by propagating a wave of silenced neuronal function through cortex and sometimes subcortical brain structures. Here, utilizing an optogenetic stimulation technique optimized to allow for non-invasive initiation of cortical SD, we demonstrate that chronic pregabalin administration [12 mg/kg/day (s.c.)] in vivo increased the threshold for cortical spreading depolarization in transgenic mice harboring the clinically-relevant Ca

Indexed as

Migraine DisordersMigraine with AuraAnimalsHippocampusMiceMice, TransgenicPregabalinPregabalinFamilial hemiplegic migrainePregabalinSpontaneous excitatory postsynaptic currentsSpreading depolarization

Identifiers

PMID37924146
PMCPMC10623724
OpenAlexW4388291700

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.