Evidence map›Paper›PMID 37924028›Full record

ArticleBMC microbiology2023

Whole genome structure and resistance genes in carbapenemase-producing multidrug resistant ST378 Klebsiella pneumoniae.

Su Min Kyung, Jun Ho Lee, Eun-Seo Lee, Cheol-Yong Hwang, Han Sang Yoo

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC microbiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.7field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 7 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 3 countries.

Su Min KyungDepartment of Infectious Disease, College of Veterinary Medicine, Seoul National University, Seoul, Republic of Korea.
Jun Ho LeeDepartment of Infectious Disease, College of Veterinary Medicine, Seoul National University, Seoul, Republic of Korea.
Eun-Seo LeeDepartment of Infectious Disease, College of Veterinary Medicine, Seoul National University, Seoul, Republic of Korea.
Cheol-Yong HwangDepartment of Veterinary Dermatology, College of Veterinary Medicine, Seoul National University, Seoul, Republic of Korea.
Han Sang YooDepartment of Infectious Disease, College of Veterinary Medicine, Seoul National University, Seoul, Republic of Korea. yoohs@snu.ac.kr.
Seoul National University · KRNew Generation University College · ET

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCarbapenemase-producing Klebsiella pneumoniae (CPKP) is one of the most dangerous multidrug-resistant (MDR) pathogens in human health due to its widespread circulation in the nosocomial environment. CPKP carried by companion dogs, which are close to human beings, should be considered a common threat to public health. However, CPKP dissemination through companion animals is still under consideration of major diagnosis and surveillance systems.

methodsTwo CPKP isolates which were genotyped to harbor bla

resultsAs a result of the whole-genome identification, 4 heterogenous plasmids and a single chromosome were identified, each carrying various AMR genes. Multiple novel structures were identified from the AMR genes, coupled with mobile gene elements (MGE). The comparative whole-genome epidemiology revealed that ST378 K. pneumoniae is a novel type of CPKP, carrying a higher prevalence of AMR genes.

conclusionsThe characterized whole-genome analysis of this study shows the emergence of a novel type of CPKP strain carrying various AMR genes with variated genomic structures. The presented data in this study show the necessity to develop additional surveillance programs and control measures for a novel type of CPKP strain.

Indexed as

Carbapenem-Resistant EnterobacteriaceaeKlebsiella InfectionsAnimalsAnti-Bacterial AgentsBacterial Proteinsbeta-LactamasesDogsDrug Resistance, Multiple, BacterialHumansKlebsiella pneumoniaeMicrobial Sensitivity TestsPhylogenyPlasmidsAnti-Bacterial AgentsBacterial Proteinsbeta-LactamasescarbapenemaseCarbapenemaseEnterobacteralesEpidemiologyKlebsiella pneumoniaeMetallo-β-LactamaseNDM-5

Identifiers

PMID37924028
PMCPMC10623767
OpenAlexW4388293990

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.