Evidence map›Paper›PMID 37923961›Full record

ArticleCommunications biology2023

A ketogenic diet can mitigate SARS-CoV-2 induced systemic reprogramming and inflammation.

Amelia Palermo, Shen Li, Johanna Ten Hoeve, Akshay Chellappa, Alexandra Morris, Barbara Dillon, Feiyang Ma, Yijie Wang, Edward Cao, Byourak Shabane and 9 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Communications biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Article
  3. Fat-rich diet promotes microbiome-dependent ATP synthesis in sheep model.Journal of animal science and biotechnology · 2025
    Article
  4. Review
  5. Article
  6. Article
  7. Review
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 4 institutions in 1 country.

Amelia Palermo *Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, CA, 90095, USA.
Shen Li *Division of Cardiology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA, 90095, USA.
Johanna Ten HoeveCalifornia Nanosystems Institute, University of California, Los Angeles, CA, 90095, USA.ORCID 0000-0003-0226-749X
Akshay ChellappaDepartment of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, CA, 90095, USA.
Alexandra MorrisDepartment of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, CA, 90095, USA.
Barbara DillonDepartment of Environment, Health and Safety, University of California, Los Angeles, CA, 90095, USA.
Feiyang MaDivision of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, 48109, USA.ORCID 0000-0002-6260-0787
Yijie WangUCLA Cardiovascular Research Theme, David Geffen School of Medicine, University of California, Los Angeles, CA, 90095, USA.ORCID 0000-0002-2681-0138
Edward CaoUCLA Cardiovascular Research Theme, David Geffen School of Medicine, University of California, Los Angeles, CA, 90095, USA.ORCID 0000-0002-1713-0851
Byourak ShabaneDepartment of Medicine, Endocrinology, David Geffen School of Medicine, University of California, Los Angeles, CA, 90095, USA.ORCID 0000-0001-9249-5917
Rebeca Acín-PerezDepartment of Medicine, Endocrinology, David Geffen School of Medicine, University of California, Los Angeles, CA, 90095, USA.ORCID 0000-0001-9553-8337
Anton PetcherskiDepartment of Medicine, Endocrinology, David Geffen School of Medicine, University of California, Los Angeles, CA, 90095, USA.ORCID 0000-0002-3143-3867
A Jake LusisCalifornia Nanosystems Institute, University of California, Los Angeles, CA, 90095, USA.ORCID 0000-0001-9013-0228
Stanley HazenDepartment of Cardiovascular and Metabolic Sciences, Cleveland Clinic, Cleveland, OH, 44195, USA.ORCID 0000-0001-7124-6639
Orian S ShirihaiCalifornia Nanosystems Institute, University of California, Los Angeles, CA, 90095, USA.ORCID 0000-0001-8466-3431
Matteo PellegriniDepartment of Molecular, Cell and Developmental Biology, Division of Life Sciences, University of California, Los Angeles, CA, 90095, USA.ORCID 0000-0001-9355-9564
Vaithilingaraja ArumugaswamiDepartment of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, CA, 90095, USA.
Thomas G GraeberDepartment of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, CA, 90095, USA. tgraeber@mednet.ucla.edu.ORCID 0000-0001-8574-9181
Arjun DebCalifornia Nanosystems Institute, University of California, Los Angeles, CA, 90095, USA. adeb@mednet.ucla.edu.ORCID 0000-0003-0978-2611
University of California, Los Angeles · USCalifornia NanoSystems Institute · USCleveland Clinic · USUniversity of Michigan · US

Funding

Metabolic and epigenetic reprogramming of vital organs in SARS-CoV-2 induced systemic toxicityR01DK132735 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARUMUGASWAMI, VAITHILINGARAJA, DEB, ARJUN · 2021 to 2023
$6.0M
Role of GPNMB in cardiac remodelingR01HL152176 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DEB, ARJUN · 2021 to 2024
$2.8M
Identifying therapeutic strategies for the multisystem genetic disorder Pseudoxanthoma ElasticumR01AR075867 · NIAMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DEB, ARJUN · 2020 to 2023
$1.4M
NHLBI NIH HHS R01 HL152176NIAMS NIH HHS R01 AR075867NIDDK NIH HHS DK132735NIDDK NIH HHS R01 DK132735
6 · The paper itself

Abstract

The ketogenic diet (KD) has demonstrated benefits in numerous clinical studies and animal models of disease in modulating the immune response and promoting a systemic anti-inflammatory state. Here we investigate the effects of a KD on systemic toxicity in mice following SARS-CoV-2 infection. Our data indicate that under KD, SARS-CoV-2 reduces weight loss with overall improved animal survival. Muted multi-organ transcriptional reprogramming and metabolism rewiring suggest that a KD initiates and mitigates systemic changes induced by the virus. We observed reduced metalloproteases and increased inflammatory homeostatic protein transcription in the heart, with decreased serum pro-inflammatory cytokines (i.e., TNF-α, IL-15, IL-22, G-CSF, M-CSF, MCP-1), metabolic markers of inflammation (i.e., kynurenine/tryptophane ratio), and inflammatory prostaglandins, indicative of reduced systemic inflammation in animals infected under a KD. Taken together, these data suggest that a KD can alter the transcriptional and metabolic response in animals following SARS-CoV-2 infection with improved mice health, reduced inflammation, and restored amino acid, nucleotide, lipid, and energy currency metabolism.

Indexed as

COVID-19Diet, KetogenicAnimalsCytokinesInflammationMiceSARS-CoV-2Cytokines

Identifiers

PMID37923961
PMCPMC10624922
OpenAlexW4388287932

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.