Evidence map›Paper›PMID 37923825›Full record

ArticleScientific reports2023

Natural killer cell responses during SARS-CoV-2 infection and vaccination in people living with HIV-1.

Aljawharah Alrubayyi, Emma Touizer, Dan Hameiri-Bowen, Bethany Charlton, Ester Gea-Mallorquí, Noshin Hussain, Kelly A S da Costa, Rosemarie Ford, Chloe Rees-Spear, Thomas A Fox and 9 more

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 5 institutions in 2 countries.

Aljawharah AlrubayyiNuffield Department of Medicine, University of Oxford, Oxford, UK.
Emma TouizerDivision of Infection and Immunity, Institute for Immunity and Transplantation, University College London, London, UK.
Dan Hameiri-BowenNuffield Department of Medicine, University of Oxford, Oxford, UK.
Bethany CharltonNuffield Department of Medicine, University of Oxford, Oxford, UK.
Ester Gea-MallorquíNuffield Department of Medicine, University of Oxford, Oxford, UK.
Noshin HussainDivision of Infection and Immunity, Institute for Immunity and Transplantation, University College London, London, UK.
Kelly A S da CostaDivision of Infection and Immunity, Institute for Immunity and Transplantation, University College London, London, UK.
Rosemarie FordDivision of Infection and Immunity, Institute for Immunity and Transplantation, University College London, London, UK.
Chloe Rees-SpearDivision of Infection and Immunity, Institute for Immunity and Transplantation, University College London, London, UK.
Thomas A FoxDivision of Infection and Immunity, Institute for Immunity and Transplantation, University College London, London, UK.
Ian WilliamsDepartment of HIV, Mortimer Market Centre, Central and North West London NHS Trust, London, UK.
Laura WatersDepartment of HIV, Mortimer Market Centre, Central and North West London NHS Trust, London, UK.
Tristan J BarberInstitute for Global Health, University College London, London, UK.
Fiona BurnsInstitute for Global Health, University College London, London, UK.
Sabine KinlochDivision of Infection and Immunity, Institute for Immunity and Transplantation, University College London, London, UK.
Emma MorrisDivision of Infection and Immunity, Institute for Immunity and Transplantation, University College London, London, UK.
Sarah Rowland-JonesNuffield Department of Medicine, University of Oxford, Oxford, UK.
Laura E McCoyDivision of Infection and Immunity, Institute for Immunity and Transplantation, University College London, London, UK.
Dimitra PeppaDivision of Infection and Immunity, Institute for Immunity and Transplantation, University College London, London, UK. d.peppa@ucl.ac.uk.
University College London · GBUniversity of Oxford · GBWest London Mental Health NHS Trust · GBMortimer Market Centre · GBRoyal Free London NHS Foundation Trust · GB

Funding

Exploiting Natural Killer cells in HIV/HBV co-infection to achieve eradicationR01AI155182 · NIAID · UNIVERSITY OF OXFORD · PI PEPPA, DIMITRA · 2020 to 2024
$1.9M
RESPIRATORY SYNCYTIAL VIRUS ON ALLERGIC AIRWAY DISEASER01AI045512 · NIAID · VANDERBILT UNIVERSITY · PI PEEBLES, RAY STOKES · 1999 to 2003
$1.2M
Department of HealthMedical Research Council MR/N013867/1Medical Research Council MR/R008698/1Medical Research Council MR/W020556/1NIAID NIH HHS R01 AI045512NIAID NIH HHS R01 AI155182Wellcome Trust
6 · The paper itself

Abstract

Natural killer (NK) cell subsets with adaptive properties are emerging as regulators of vaccine-induced T and B cell responses and are specialized towards antibody-dependent functions contributing to SARS-CoV-2 control. Although HIV-1 infection is known to affect the NK cell pool, the additional impact of SARS-CoV-2 infection and/or vaccination on NK cell responses in people living with HIV (PLWH) has remained unexplored. Our data show that SARS-CoV-2 infection skews NK cells towards a more differentiated/adaptive CD57

Indexed as

COVID-19HIV-1HIV InfectionsVaccinesAntibodiesAntibodies, ViralHumansKiller Cells, NaturalSARS-CoV-2VaccinationAntibodiesAntibodies, ViralVaccines

Identifiers

PMID37923825
PMCPMC10624865
OpenAlexW4388292503

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.