Evidence map›Paper›PMID 37923731›Full record

ArticleScientific data2023

Transcriptional profiling of early differentiation of primary human mesenchymal stem cells into chondrocytes.

Thomas Schwarzl, Andrea Keogh, Georgina Shaw, Aleksandar Krstic, Elizabeth Clayton, Desmond G Higgins, Walter Kolch, Frank Barry

Open access · goldAbstract readDataset
In one paragraph

Article in Scientific data, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
3.2field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
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  7. Article
  8. Mesenchymal Stromal Cells for Aging Cartilage Regeneration: A Review.International journal of molecular sciences · 2024
    Review
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Thomas SchwarzlEuropean Molecular Biology Laboratory (EMBL), Meyerhofstraße 1, 69117, Heidelberg, Germany.ORCID 0000-0001-7697-7000
Andrea KeoghPreviously: Regenerative Medicine Institute (REMEDI), Biosciences, National University of Ireland Galway, University Road, Galway, Ireland.
Georgina ShawRegenerative Medicine Institute (REMEDI), Biosciences, National University of Ireland Galway, University Road, Galway, Ireland.
Aleksandar KrsticSystems Biology Ireland (SBI), School of Medicine, University College Dublin, Dublin, 4, Ireland.
Elizabeth ClaytonPreviously: Regenerative Medicine Institute (REMEDI), Biosciences, National University of Ireland Galway, University Road, Galway, Ireland.
Desmond G HigginsSystems Biology Ireland (SBI), School of Medicine, University College Dublin, Dublin, 4, Ireland.
Walter KolchSystems Biology Ireland (SBI), School of Medicine, University College Dublin, Dublin, 4, Ireland. Walter.Kolch@ucd.ie.ORCID 0000-0001-5777-5016
Frank BarryRegenerative Medicine Institute (REMEDI), Biosciences, National University of Ireland Galway, University Road, Galway, Ireland.
Ollscoil na Gaillimhe – University of Galway · IEUniversity College Dublin · IEEuropean Molecular Biology Laboratory · DE

Funding

Science Foundation Ireland (SFI) 06/CE/B1129Science Foundation Ireland (SFI) 18/SPP/3522
6 · The paper itself

Abstract

Articular cartilage has only very limited regenerative capacities in humans. Tissue engineering techniques for cartilage damage repair are limited in the production of hyaline cartilage. Mesenchymal stem/stromal cells (MSCs) are multipotent stem cells and can be differentiated into mature cartilage cells, chondrocytes, which could be used for repairing damaged cartilage. Chondrogenesis is a highly complex, relatively inefficient process lasting over 3 weeks in vitro. Methods: In order to better understand chondrogenic differentiation, especially the commitment phase, we have performed transcriptional profiling of MSC differentiation into chondrocytes from early timepoints starting 15 minutes after induction to 16 hours and fully differentiated chondrocytes at 21 days in triplicates.

Indexed as

Cell DifferentiationChondrocytesMesenchymal Stem CellsCartilage, ArticularHumansTranscriptome

Identifiers

PMID37923731
PMCPMC10624874
OpenAlexW4388303497

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.