Evidence map›Paper›PMID 37923668›Full record

ArticleSleep health2023

Associations of adverse childhood and lifetime experiences with sleep quality and duration among women in midlife.

Emily Oken, Sheryl L Rifas-Shiman, Hadine Joffe, JoAnn E Manson, Primavera Alessandra Spagnolo, Suzanne M Bertisch, Elizabeth B Klerman, Jorge E Chavarro

Open access · greenAbstract read
In one paragraph

Article in Sleep health, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Emily OkenDivision of Chronic Disease Research Across the Lifecourse, Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA, USA; Department of Nutrition, Harvard TH Chan School of Public Health, Boston, MA, USA. Electronic address: emily_oken@hphci.harvard.edu.
Sheryl L Rifas-ShimanDepartment of Nutrition, Harvard TH Chan School of Public Health, Boston, MA, USA.
Hadine JoffeDepartment of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA; Connors Center for Women Health and Gender Biology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
JoAnn E MansonConnors Center for Women Health and Gender Biology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA; Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Primavera Alessandra SpagnoloDepartment of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA; Connors Center for Women Health and Gender Biology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Suzanne M BertischDepartment of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA; Division of Sleep Medicine, Harvard Medical School, Boston, MA, USA.
Elizabeth B KlermanDepartment of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA; Division of Sleep Medicine, Harvard Medical School, Boston, MA, USA; Department of Neurology, Massachusetts General Hospital, Boston, MA, USA.
Jorge E ChavarroDepartment of Nutrition, Harvard TH Chan School of Public Health, Boston, MA, USA.
Brigham and Women's Hospital · USHarvard University · US

Funding

Prenatal environmental determinants of health in young adulthood: a lifecourse approachR01HD034568 · NICHD · HARVARD PILGRIM HEALTH CARE, INC. · PI Marie-France Hivert, Emily Oken · 1998 to 2026
$20.6M
The roles of NK3RMnPO and KNDy neurons in vasomotor symptoms, sleep, and cognition in E2 depleted mice.U54AG062322 · NIA · BRIGHAM AND WOMEN'S HOSPITAL · PI KATHRYN M REXRODE · 2020 to 2026
$13.7M
A Dose Selection Trial of Light Therapy for Impaired Sleep in Parkinson's DiseaseU01NS114001 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI VIDENOVIC, ALEKSANDAR · 2019 to 2021
$6.5M
Molecular and Physiological Mechanisms of Hypertensive Cerebral MicroangiopathyR01NS114526 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI GUROL, MAHMUT EDIP · 2020 to 2024
$4.4M
A lifecourse approach to women's mental health: from fertility to perimenopauseR01HD096032 · NICHD · HARVARD PILGRIM HEALTH CARE, INC. · PI CHAVARRO, JORGE EDUARDO, OKEN, EMILY · 2019 to 2023
$3.6M
Influence of sleep regularity on circadian rhythms, learning, performance, and moodR01HL128538 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI KLERMAN, ELIZABETH B. · 2016 to 2019
$3.6M
Bright light modulation of non-motor symptoms in Parkinson's diseaseR01NS099055 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI VIDENOVIC, ALEKSANDAR · 2017 to 2021
$3.0M
Testing Effects of Melatonin on Uterine Contractions in WomenR01HD107064 · NICHD · MASSACHUSETTS GENERAL HOSPITAL · PI KLERMAN, ELIZABETH B. · 2022 to 2025
$3.0M
Maintain and Enrich Resource Infrastructure for Project Viva: a pre-birth cohort with follow up into adolescenceR24ES030894 · NIEHS · HARVARD PILGRIM HEALTH CARE, INC. · PI OKEN, EMILY · 2020 to 2024
$2.0M
Impact of sex and age on non-visual light input that affects sleep and circadian rhythmsR01HL166205 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI KLERMAN, ELIZABETH B. · 2023 to 2025
$1.6M
A hybrid effectiveness-implementation trial evaluating behavioral treatments for insomnia for socioeconomic disadvantaged adults in primary careR61HL164688 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI BERTISCH, SUZANNE · 2022 to 2022
$563k
Treatment of Restless Legs Symptoms with Pramipexole to Improve the Outcomes of Protracted Opioid Withdrawal in OUD: A Pilot Double-blind, Randomized Clinical TrialR21DA052861 · NIDA · MASSACHUSETTS GENERAL HOSPITAL · PI WINKELMAN, JOHN W · 2021 to 2022
$462k
NHLBI NIH HHS R01 HL128538NHLBI NIH HHS R01 HL166205NHLBI NIH HHS R61 HL164688NIA NIH HHS U54 AG062322NICHD NIH HHS R01 HD034568NICHD NIH HHS R01 HD096032NICHD NIH HHS R01 HD107064NIDA NIH HHS R21 DA052861NIEHS NIH HHS R24 ES030894NINDS NIH HHS R01 NS099055NINDS NIH HHS R01 NS114526NINDS NIH HHS U01 NS114001
6 · The paper itself

Abstract

objectivesMany women experience sleep problems during midlife. Associations of adverse lifetime experiences-more common among women-with sleep outcomes are understudied.

methodsWe studied 476 women enrolled in Project Viva 1999-2002. At enrollment, participants reported any lifetime history of abuse and/or financial hardship. At midlife follow-up ∼20 years later, they reported a history of up to 10 adverse childhood experiences (ACEs); 7-day sleep quality (patient-reported outcomes measurement information system sleep disturbance and sleep-related impairment T-scores); and past month average sleep duration. We examined associations of adverse experiences with sleep outcomes, adjusted for childhood sociodemographic variables. We also explored mediation by current depression and anxiety symptoms, hot flash severity, general health, and body mass index.

resultsACEs were common: 301 women (63%) reported one or more. Each additional ACE was associated with higher midlife sleep disturbance (adjusted β = 0.65 points, 95% confidence interval [CI]: 0.27, 1.02) and sleep-related impairment (0.98, 95% CI: 0.54, 1.41) T-scores, and with sleep duration <6 hour/night (odds ratio 1.19, 95% CI: 1.00, 1.42), but not with continuous sleep duration (-2 minutes, 95% CI: -5, 1). Adverse experiences in adulthood were less consistently associated with sleep quality but were associated with sleep duration, for example, financial hardship during the index pregnancy was associated with 75 minutes (95% CI: -120, -29) shorter sleep duration 2 decades later. Associations of ACEs with sleep disturbance and sleep-related impairment were mediated by midlife depression anxiety and physical health but not by hot flash severity or body mass index.

conclusionsAdverse lifetime experiences have deleterious associations with sleep duration and quality in midlife women.

Indexed as

Child AbuseSleep Wake DisordersAnxietyChildFemaleHumansPregnancySleepSleep QualityAbuseAdverse childhood experiencesHardshipMidlifeSleepWomen’s health

Identifiers

PMID37923668
PMCPMC10840935
OpenAlexW4388114816

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.