Evidence map›Paper›PMID 37923359›Full record

ArticleLife science alliance2024

Integrins regulate hERG1 dynamics by girdin-dependent Gαi3: signaling and modeling in cancer cells.

Claudia Duranti, Jessica Iorio, Giacomo Bagni, Ginevra Chioccioli Altadonna, Thibault Fillion, Matteo Lulli, Franco Nicolas D'Alessandro, Alberto Montalbano, Elena Lastraioli, Duccio Fanelli and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Life science alliance, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 5 institutions in 3 countries.

Claudia DurantiDepartment of Experimental and Clinical Medicine, Section of Internal Medicine, University of Florence, Florence, Italy.
Jessica IorioDepartment of Experimental and Clinical Medicine, Section of Internal Medicine, University of Florence, Florence, Italy.
Giacomo BagniDepartment of Experimental and Clinical Medicine, Section of Internal Medicine, University of Florence, Florence, Italy.
Ginevra Chioccioli AltadonnaDepartment of Experimental and Clinical Medicine, Section of Internal Medicine, University of Florence, Florence, Italy.ORCID https://orcid.org/0000-0002-9747-0783
Thibault FillionDepartment of Physics, University of Florence, and Florence Section of INFN, Florence, Italy.
Matteo LulliDepartment of Experimental and Clinical Biochemical Sciences, Section of General Pathology, University of Florence, Florence, Italy.
Franco Nicolas D'AlessandroDepartment of Experimental and Clinical Medicine, Section of Internal Medicine, University of Florence, Florence, Italy.
Alberto MontalbanoDepartment of Experimental and Clinical Medicine, Section of Internal Medicine, University of Florence, Florence, Italy.ORCID https://orcid.org/0000-0002-5336-5412
Elena LastraioliDepartment of Experimental and Clinical Medicine, Section of Internal Medicine, University of Florence, Florence, Italy.ORCID https://orcid.org/0000-0002-1531-8973
Duccio FanelliDepartment of Physics, University of Florence, and Florence Section of INFN, Florence, Italy.
Stefano CoppolaDepartment of Physics, University of Leiden, Leiden, Netherlands.
Thomas SchmidtDepartment of Physics, University of Leiden, Leiden, Netherlands.
Francesco PiazzaDepartment of Physics, University of Florence, and Florence Section of INFN, Florence, Italy.
Andrea BecchettiDepartment of Biotechnology and Biosciences, University of Milano Bicocca, Milan, Italy.ORCID https://orcid.org/0000-0002-9297-0527
Annarosa ArcangeliDepartment of Experimental and Clinical Medicine, Section of Internal Medicine, University of Florence, Florence, Italy annarosa.arcangeli@unifi.it.ORCID https://orcid.org/0000-0002-6317-9648
University of Florence · ITLeiden University · NLUniversité d'Orléans · FRUniversity of Siena · ITUniversity of Milano-Bicocca · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The hERG1 potassium channel is aberrantly over expressed in tumors and regulates the cancer cell response to integrin-dependent adhesion. We unravel a novel signaling pathway by which integrin engagement by the ECM protein fibronectin promotes hERG1 translocation to the plasma membrane and its association with β1 integrins, by activating girdin-dependent Gαi3 proteins and protein kinase B (Akt). By sequestering hERG1, β1 integrins make it avoid Rab5-mediated endocytosis, where unbound channels are degraded. The cycle of hERG1 expression determines the resting potential (V

Indexed as

IntegrinsNeoplasmsEther-A-Go-Go Potassium ChannelsGTP-Binding Protein alpha Subunits, Gi-GoHumansIntegrin beta1Microfilament ProteinsSignal TransductionVesicular Transport ProteinsCCDC88A protein, humanEther-A-Go-Go Potassium ChannelsGNAI3 protein, humanGTP-Binding Protein alpha Subunits, Gi-GoIntegrin beta1IntegrinsKCNH1 protein, humanMicrofilament ProteinsVesicular Transport Proteins

Identifiers

PMID37923359
PMCPMC10624597
OpenAlexW4388288078

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.