ArticleImmunity2023
Single-cell epigenetic, transcriptional, and protein profiling of latent and active HIV-1 reservoir revealed that IKZF3 promotes HIV-1 persistence.
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Article in Immunity, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.
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50citing papers in PubMed
9.2field-weighted citation impact, top 1% of its field
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Who cites it
50 citing papers in PubMed, 65 citations in OpenAlex.
- Trial
- The immunophenotype and proviral landscape of HIV-infected CD4 T cells during antiretroviral therapy.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- The Rectal Mucosal Myeloid Niche in HIV-1 Persistence: Reservoir Support, Viral Sequestration, and Therapeutic Opportunities.Viruses · 2026Review
- IRF1 regulates apoptosis and osteogenic differentiation of bone marrow mesenchymal stem cells and ameliorates osteoporosis by activating the PI3K/AKT signaling pathway.Journal of advanced research · 2026Article
- Three immunoregulatory signatures define non-productive HIV infection in stem cell memory CD4Nature communications · 2026Article
- Is the molecular microenvironment of the latent HIV reservoir predictable using deep learning approaches?Journal of virology · 2026Review
- Autologous neutralizing antibodies and polyfunctional T cells contribute to long-term HIV-1 post-intervention control.Nature immunology · 2026Article
- Three immunoregulatory signatures define non-productive HIV infection in CD4bioRxiv : the preprint server for biology · 2026Article
- Review
- HIV-seq reveals gene expression differences between HIV-transcribing cells from viremic and suppressed people with HIV.Nature communications · 2026Article
- Transcription of HIV-1 is heterogenous among authentic latent CD4+ T cell clones.The Journal of experimental medicine · 2026Article
- Q4ddPCR: a flexible, 4-target assay for high-resolution HIV reservoir profiling.Nature communications · 2026Article
- Cytotoxic CD4 T Cells: Dual Agents in HIV-1 Pathogenesis and Persistence.Current HIV/AIDS reports · 2026Review
- Single-cell characterization of the gastrointestinal HIV reservoir reveals heterogeneous cellular phenotypes.The Journal of clinical investigation · 2026Article
- HIV-1 Integration Site Determines the Transcriptional Fate and Persistence of Integrated Proviruses.bioRxiv : the preprint server for biology · 2026Article
- Global research landscape and trends of single-cell sequencing in sexually transmitted infections: a comprehensive bibliometric analysis from 2015 to 2025.Frontiers in reproductive health · 2026Article
- Epigenetic mechanisms of HIV and opioid-induced neuropathology: Potential therapies and interventions.Molecular therapy : the journal of the American Society of Gene Therapy · 2025Review
- Transcription factor BACH2 shapes tissue-resident memory T cell programs to promote HIV-1 persistence.Immunity · 2025Article
- Resist to persist: resistance of the HIV reservoir to immune-mediated clearance.Current opinion in HIV and AIDS · 2025Review
- The tuberculosis-associated microenvironment promotes HIV-1 persistence by impairing CD8+ T cell-mediated viral control.bioRxiv : the preprint server for biology · 2025Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 2 countries.
Yulong WeiDepartment of Microbial Pathogenesis, Yale University School of Medicine, New Haven, CT 06519, USA.
Timothy C DavenportDepartment of Microbial Pathogenesis, Yale University School of Medicine, New Haven, CT 06519, USA.
Jack A ColloraDepartment of Microbial Pathogenesis, Yale University School of Medicine, New Haven, CT 06519, USA.
Haocong Katherine MaDepartment of Microbial Pathogenesis, Yale University School of Medicine, New Haven, CT 06519, USA.
Delia Pinto-SantiniVaccine and Infectious Disease, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
Javier LamaAsociación Civil Impacta Salud y Educación, Lima 15063, Perú.
Ricardo AlfaroCentro de Investigaciones Tecnológicas Biomédicas y Medioambientales (CITBM), Lima 07006, Perú.
Ann DuerrVaccine and Infectious Disease, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
Ya-Chi HoDepartment of Microbial Pathogenesis, Yale University School of Medicine, New Haven, CT 06519, USA. Electronic address: ya-chi.ho@yale.edu.
Yale University · USFred Hutch Cancer Center · USAsociación Civil Impacta Salud y Educación · PE
Funding
BEAT-HIV: Delaney Collaboratory to Cure HIV-1 Infection by Combination ImmunotherapyUM1AI164570 · NIAID · WISTAR INSTITUTE · PI Luis J Montaner, James L. Riley · 2021 to 2026
$34.7MCHEETAH Center for the Structural Biology of HIV Infection, Restriction, and Viral DynamicsU54AI170856 · NIAID · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI JOSEPH D PUGLISI · 2022 to 2026
$34.4MREACH: Research Enterprise to Advance a Cure for HIVUM1AI164565 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI Marina Caskey, R. Brad Jones · 2021 to 2026
$32.9MFirst-in-human study of two anti-SARS CoV-2 antibodies in health volunteersUM1AI126620 · NIAID · WISTAR INSTITUTE · PI MONTANER, LUIS J, RILEY, JAMES L. · 2016 to 2021
$24.5MThe Y-SCORCH Data Generation Center at Yale for Single-Cell Opioid Responses in the Context of HIVUM1DA051410 · NIDA · YALE UNIVERSITY · PI GERSTEIN, MARK BENDER, KLUGER, YUVAL · 2020 to 2025
$15.3MVirus TransmissionP50AI150464 · NIAID · UNIVERSITY OF UTAH · PI BJORKMAN, PAMELA J · 2019 to 2021
$14.9MHigh-Definition Characterization of the Persistence and Perturbation of the HIV Reservoir: Project 3P01AI169768 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI Athe M. Tsibris · 2022 to 2026
$10.1MM-SCORCH: Methamphetamine use disorder data generation center for Single Cell Opioid Responses in the Context of HIVU01DA053628 · NIDA · YALE UNIVERSITY · PI HO, YA-CHI, SESTAN, NENAD · 2021 to 2025
$9.5MModulating the Impact of Critical Events in Early HIV Infection: Effect of Early ART Initiation and Alcohol UseR01DA040532 · NIDA · FRED HUTCHINSON CANCER RESEARCH CENTER · PI DUERR, ANN C · 2015 to 2019
$8.0MHIV Testing and Treatment to Prevent Onward HIV Transmission among High-risk MSMR01DA032106 · NIDA · FRED HUTCHINSON CANCER RESEARCH CENTER · PI DUERR, ANN C · 2011 to 2015
$6.6MThe HUSH complex in HIV-1 latencyR37AI147868 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI JEREMY LUBAN · 2019 to 2026
$6.4MRole of clonal expansion in HIV-1 persistenceR01AI141009 · NIAID · YALE UNIVERSITY · PI Ya-Chi Ho · 2018 to 2026
$5.3MNIAID NIH HHS P01 AI169768NIAID NIH HHS P50 AI150464NIAID NIH HHS R01 AI141009NIAID NIH HHS R01 AI145164NIAID NIH HHS R01 AI174863NIAID NIH HHS R37 AI147868NIAID NIH HHS T32 AI055403NIAID NIH HHS U54 AI170856NIAID NIH HHS UM1 AI126620NIAID NIH HHS UM1 AI164565NIAID NIH HHS UM1 AI164570NIDA NIH HHS R01 DA032106NIDA NIH HHS R01 DA040532NIDA NIH HHS R01 DA051906NIDA NIH HHS R33 DA047037NIDA NIH HHS R61 DA047037NIDA NIH HHS U01 DA053628NIDA NIH HHS UM1 DA051410
Abstract
Understanding how HIV-1-infected cells proliferate and persist is key to HIV-1 eradication, but the heterogeneity and rarity of HIV-1-infected cells hamper mechanistic interrogations. Here, we used single-cell DOGMA-seq to simultaneously capture transcription factor accessibility, transcriptome, surface proteins, HIV-1 DNA, and HIV-1 RNA in memory CD4
Indexed as
HIV-1HIV InfectionsCD4-Positive T-LymphocytesEpigenesis, GeneticHumansIkaros Transcription FactorTranscription Factor AP-1Virus LatencyIkaros Transcription FactorIKZF3 protein, humanTranscription Factor AP-1acute viral infectionAiolosHIV cureHIV latent reservoirHIV persistenceIKZF3memory CD4(+) T cellssingle-cell ATAC-seqsingle-cell RNA-seqT cell differentiationtranscription factor
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.