Evidence map›Paper›PMID 37922732›Full record

ArticlePsychiatry research2023

The effect of zolpidem-CR on the suicide item of the Hamilton Rating Scale for Depression in outpatients with depression, insomnia and suicidal ideation: Lessons learned.

William V McCall, Kayla Mercado, Tess N Dzurny, Laryssa L McCloud, Andrew D Krystal, Ruth M Benca, Peter B Rosenquist, Stephen W Looney

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Psychiatry research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Trial
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

William V McCallDepartment of Psychiatry and Health Behavior, Medical College of Georgia, Augusta University, 997St Sebastian Way, Augusta GA 30909, USA. Electronic address: wmccall@augusta.edu.
Kayla MercadoDepartment of Population Health Sciences, Medical College of Georgia, Augusta University, 1120 15th St, Augusta, GA 30912.
Tess N DzurnyDepartment of Psychiatry and Health Behavior, Medical College of Georgia, Augusta University, 997St Sebastian Way, Augusta GA 30909, USA.
Laryssa L McCloudDepartment of Psychiatry and Health Behavior, Medical College of Georgia, Augusta University, 997St Sebastian Way, Augusta GA 30909, USA.
Andrew D KrystalDepartment of Psychiatry and Behavioral Sciences, University of California, San Francisco, 675 18th St, San Francisco, CA 94143, USA.
Ruth M BencaDepartment of Psychiatry and Behavioral Medicine, Wake Forest University School of Medicine, 791 Jonestown Rd, Winston-Salem, NC 27103, USA.
Peter B RosenquistDepartment of Psychiatry and Health Behavior, Medical College of Georgia, Augusta University, 997St Sebastian Way, Augusta GA 30909, USA.
Stephen W LooneyPrivate consultant, 805 Heard Ave., Augusta, GA 30904.

Funding

1/3-Reducing Suicial Ideation Through Insomnia Treatment (REST-IT)R01MH095776 · NIMH · AUGUSTA UNIVERSITY · PI MCCALL, WILLIAM VAUGHN · 2012 to 2016
$1.2M
3/3-Reducing Suicidal Ideation Through Insomnia Treatment (REST-IT)R01MH095778 · NIMH · UNIVERSITY OF WISCONSIN-MADISON · PI BENCA, RUTH M · 2012 to 2016
$991k
2/3-Reducing Suicide Ideation Through Insomnia Treatment (REST-IT)R01MH095780 · NIMH · DUKE UNIVERSITY · PI KRYSTAL, ANDREW D · 2012 to 2016
$904k
NIMH NIH HHS R01 MH095776NIMH NIH HHS R01 MH095778NIMH NIH HHS R01 MH095780
6 · The paper itself

Abstract

The REST-IT study found the addition of zolpidem-controlled release (CR) provided a significant reduction in observer-rated measurement of suicidal ideation (the Columbia Suicide Severity Rating Scale) in 103 depressed outpatients with insomnia and suicidal ideation, but without significant change in a self-report measure of suicidal ideation (the Scale for Suicide Ideation). This secondary analysis of the REST-IT data examined the suicide item of another observer-rated scale, the Hamilton Rating Scale for Depression (HRSD), further clarifying the impact of insomnia-focused treatment on suicidal ideation. This analysis established a significant advantage for zolpidem-CR compared with placebo on the HRSD suicide item.

Indexed as

Sleep Initiation and Maintenance DisordersDepressionHumansOutpatientsPsychiatric Status Rating ScalesSuicidal IdeationZolpidemZolpidemHypnoticObserver-ratedSelf-report

Identifiers

PMID37922732
PMCPMC10847958

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.