Evidence map›Paper›PMID 37922501›Full record

ArticleEuropean journal of neurology2024

Hypersomnia in anti-glutamic acid decarboxylase 65 (GAD65) associated neurological syndromes: A pilot study.

Lina Jeantin, Ana Gales, Giulia Berzero, Smaranda Leu, Jérémy Proust, Marine Giry, Nefeli Eirini Valyraki, Cristina Birzu, Agusti Alentorn, Marie Vidailhet and 2 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of neurology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 2 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Lina JeantinSleep Disorders Unit, R3S Department, Pitié-Salpêtrière Hospital, AP-HP Sorbonne University, Paris, France.ORCID 0000-0001-6888-3311
Ana GalesSleep Disorders Unit, R3S Department, Pitié-Salpêtrière Hospital, AP-HP Sorbonne University, Paris, France.ORCID 0000-0002-9431-0581
Giulia BerzeroNeuro-Oncology Unit, Neurology Department, Pitié-Salpêtrière Hospital, AP-HP Sorbonne University, Paris, France.
Smaranda LeuSleep Disorders Unit, R3S Department, Pitié-Salpêtrière Hospital, AP-HP Sorbonne University, Paris, France.
Jérémy ProustSleep Disorders Unit, R3S Department, Pitié-Salpêtrière Hospital, AP-HP Sorbonne University, Paris, France.
Marine GiryNeuro-Oncology Unit, Neurology Department, Pitié-Salpêtrière Hospital, AP-HP Sorbonne University, Paris, France.
Nefeli Eirini ValyrakiNeuro-Oncology Unit, Neurology Department, Pitié-Salpêtrière Hospital, AP-HP Sorbonne University, Paris, France.
Cristina BirzuNeuro-Oncology Unit, Neurology Department, Pitié-Salpêtrière Hospital, AP-HP Sorbonne University, Paris, France.
Agusti AlentornNeuro-Oncology Unit, Neurology Department, Pitié-Salpêtrière Hospital, AP-HP Sorbonne University, Paris, France.
Marie VidailhetMovement Disorder Unit, Neurology Department, Pitié-Salpêtrière Hospital, Paris, France.
Dimitri PsimarasNeuro-Oncology Unit, Neurology Department, Pitié-Salpêtrière Hospital, AP-HP Sorbonne University, Paris, France.
Isabelle ArnulfSleep Disorders Unit, R3S Department, Pitié-Salpêtrière Hospital, AP-HP Sorbonne University, Paris, France.
Sorbonne Université · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

background and purposeDespite their detrimental impact on the quality of life in autoimmune encephalitis, sleep disorders have not been investigated in anti-glutamic acid decarboxylase (GAD65) associated neurological syndromes.

methodsSix consecutive adult patients diagnosed with anti-GAD65-associated neurological syndromes (four with limbic encephalitis and two with stiff-person syndrome) and 12 healthy controls were enrolled. Participants underwent sleep interviews and sleep studies including night-time video-polysomnography, followed by five daytime multiple sleep latency tests (MSLTs, to assess propensity to fall asleep) and an 18 h bed rest polysomnography (to assess excessive sleep need).

resultsPatients reported the need for daily naps and that their cognition and quality of life were altered by sleepiness, but they had normal scores on the Epworth sleepiness scale. Compared with controls, sleep latencies during the MSLT were shorter in the patient group (median 5.8 min, interquartile range [IQR] 4.5, 6.0 vs. 17.7 min, IQR 16.3, 19.7, p = 0.001), and the arousal index was reduced (2.5/h, IQR 2.3, 3.0 vs. 22.3/h, IQR 13.8, 30.0, p = 0.002), although total sleep time was similar between groups (621 min, IQR 464, 651 vs. 542.5 min, IQR 499, 582, p = 0.51). Remarkably, all six patients had MSLT latencies ≤8 min, indicating severe sleepiness. No parasomnia or sleep-disordered breathing was detected.

conclusionCentral hypersomnia is a relevant characteristic of anti-GAD65-associated neurological syndromes.

Indexed as

Carboxy-LyasesDisorders of Excessive SomnolenceAdultHumansPilot ProjectsQuality of LifeSleepinessCarboxy-Lyasesautoimmune diseases of the nervous systemencephalitisepilepsyhypersomniahypersomnolencestiff-person syndrome

Identifiers

PMID37922501
PMCPMC11235746
OpenAlexW4388281000

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.