Evidence map›Paper›PMID 37922371›Full record

ArticleTransplant infectious disease : an official journal of the Transplantation Society2023

Post-acute sequelae of COVID-19 in solid organ transplant recipients.

Rachel Sigler, Karina Covarrubias, Benjamin Chen, Rodrigo Barriola Rubarth, Kelly Torosian, Claudia Ramirez Sanchez, Ajay Bharti, Victor DeGruttola, Saima Aslam

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Transplant infectious disease : an official journal of the Transplantation Society, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.0field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Observational
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 1 country.

Rachel SiglerDivision of Infectious Diseases, The University of Kansas Health System, Kansas City, Kansas, USA.ORCID https://orcid.org/0000-0002-8861-1150
Karina CovarrubiasDivision of Transplant and Hepatobiliary Surgery, Department of Surgery, University of California, San Diego, San Diego, California, USA.
Benjamin ChenDivision of Infectious Disease and Global Public Health, Department of Medicine, University of California, San Diego, San Diego, California, USA.
Rodrigo Barriola RubarthDepartment of Medicine, University of California, San Diego, San Diego, California, USA.
Kelly TorosianDepartment of Medicine, University of California, San Diego, San Diego, California, USA.
Claudia Ramirez SanchezDivision of Transplant and Hepatobiliary Surgery, Department of Surgery, University of California, San Diego, San Diego, California, USA.
Ajay BhartiDivision of Transplant and Hepatobiliary Surgery, Department of Surgery, University of California, San Diego, San Diego, California, USA.
Victor DeGruttolaDepartment of Biostatistics, Harvard University School of Public Health, Boston, Massachusetts, USA.
Saima AslamDivision of Transplant and Hepatobiliary Surgery, Department of Surgery, University of California, San Diego, San Diego, California, USA.ORCID https://orcid.org/0000-0002-4051-5629
University of San Diego · USUniversity of California San Diego · USBoston University · USUniversity of California System · USUniversity of Kansas · US

Funding

San Diego Biomedical Informatics Education & Research (SABER)T15LM011271 · NLM · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SHAMIM NEMATI · 2012 to 2026
$9.7M
NLM NIH HHS T15 LM011271NLM NIH HHS T15LM011271
6 · The paper itself

Abstract

backgroundPost-acute sequelae of coronavirus disease 2019 (COVID-19) (PASC), defined as prolonged symptoms following an episode of COVID-19, is not well-characterized in solid organ transplant recipients (SOTR). In this study, we aimed to assess the prevalence of PASC in SOTR, its descriptive characteristics, and associated risk factors.

methodsWe retrospectively identified SOTRs with acute COVID-19 between June 1, 2020 and April 15, 2022, and abstracted demographic and medical history, characteristics of acute COVID-19 illness, and COVID-19 vaccination status. We defined PASC as ongoing/new symptoms present at 6 weeks or longer following acute COVID-19 diagnosis.

resultsAmong 208 SOTRs with acute COVID-19, 72 (35%) developed PASC. Common symptoms were respiratory symptoms (67%), headache (40%), and difficulty concentrating (10%). Severe acute COVID-19 disease and presence of respiratory symptoms were associated with higher odds of PASC in multivariable analyses, while receipt of at least one COVID-19 vaccination prior to transplantation was protective.

conclusionWe found that PASC occurs in about a third of SOTRs with acute COVID-19 and has similar symptoms as described previously in immunocompetent hosts. Pre-transplant vaccination may be protective. Further prospective multicenter studies are needed.

Indexed as

COVID-19COVID-19 VaccinesOrgan TransplantationTransplant RecipientsCOVID-19 TestingDisease ProgressionHumansPost-Acute COVID-19 SyndromeRetrospective StudiesCOVID-19 VaccinesCOVID-19immunocompromiselong COVIDpost-acute sequelae of COVID-19solid organ transplant

Identifiers

PMID37922371
PMCPMC10841400
OpenAlexW4388284317

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.