ArticleeLife2023
Awake responses suggest inefficient dense coding in the mouse retina.
Article in eLife, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Action potential propagation in the rodent myelinated optic nerve does not trigger neurovascular coupling.Nature communications · 2026Article
- Absence of local retinotopy in the mouse optic tract.Frontiers in neural circuits · 2026Article
- The central histaminergic system slows visual processing in the retina and lateral geniculate nucleus of awake mice.PLoS biology · 2025Article
- When the brain talks back to the eye.PLoS biology · 2025Article
- Atypical cortical feedback underlies failure to process contextual information in the superior colliculus of Scn2aNature communications · 2025Article
- Effects of corticothalamic feedback depend on visual responsiveness and stimulus type.iScience · 2025Article
- Neuroimaging Model of Visceral Manipulation in an Awake Rat.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Article
- Topographic axonal projection at single-cell precision supports local retinotopy in the mouse superior colliculus.Nature communications · 2023Article
- Putting early sensory neurons to sleep.eLife · 2023Article
- Article
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Abstract
The structure and function of the vertebrate retina have been extensively studied across species with an isolated, ex vivo preparation. Retinal function in vivo, however, remains elusive, especially in awake animals. Here, we performed single-unit extracellular recordings in the optic tract of head-fixed mice to compare the output of awake, anesthetized, and ex vivo retinas. While the visual response properties were overall similar across conditions, we found that awake retinal output had in general (1) faster kinetics with less variability in the response latencies; (2) a larger dynamic range; and (3) higher firing activity, by ~20 Hz on average, for both baseline and visually evoked responses. Our modeling analyses further showed that such awake response patterns convey comparable total information but less efficiently, and allow for a linear population decoder to perform significantly better than the anesthetized or ex vivo responses. These results highlight distinct retinal behavior in awake states, in particular suggesting that the retina employs dense coding in vivo, rather than sparse efficient coding as has been often assumed from ex vivo studies.
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