Evidence map›Paper›PMID 37922096›Full record

ArticlePflugers Archiv : European journal of physiology2024

Effect of salivary gland removal on taste preference in mice.

Masataka Narukawa, Rina Matsuda, Ippei Watari, Takashi Ono, Takumi Misaka

Erratum issuedAbstract read
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In one paragraph

Article in Pflugers Archiv : European journal of physiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Masataka NarukawaDepartment of Food and Nutrition, Kyoto Women's University, 35 Imakumano, Higashiyama-Ku, Kyoto City, Kyoto, 605-8501, Japan. narukawa@kyoto-wu.ac.jp.ORCID 0000-0003-2181-1956
Rina MatsudaDepartment of Food and Nutrition, Kyoto Women's University, 35 Imakumano, Higashiyama-Ku, Kyoto City, Kyoto, 605-8501, Japan.
Ippei WatariDepartment of Orthodontic Science, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), 1-5-45 Yushima, Bunkyo City, Tokyo, 113-8510, Japan.ORCID 0000-0002-1484-0639
Takashi OnoDepartment of Orthodontic Science, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), 1-5-45 Yushima, Bunkyo City, Tokyo, 113-8510, Japan.ORCID 0000-0002-8043-660X
Takumi MisakaDepartment of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo City, Tokyo, 113-8657, Japan.ORCID 0000-0002-9547-5767
Kyoto Women's University · JPTokyo Medical and Dental University · JPThe University of Tokyo · JP

Funding

Japan Society for the Promotion of Science 19H02905Salt Science Research Foundation 2046
6 · The paper itself

Abstract

To evaluate the effect of decreased salivary secretion on taste preference, we investigated taste preference for five basic tastes by a 48 h two-bottle preference test using a mouse model (desalivated mice) that underwent surgical removal of three major salivary glands: the parotid, submandibular, and sublingual glands. In the desalivated mice, the avoidance behaviors for bitter and salty tastes and the attractive behaviors for sweet and umami tastes were significantly decreased. We confirmed that saliva is necessary to maintain normal taste preference. To estimate the cause of the preference changes, we investigated the effects of salivary gland removal on the expression of taste-related molecules in the taste buds. No apparent changes were observed in the expression levels or patterns of taste-related molecules after salivary gland removal. When the protein concentration and composition in the saliva were compared between the control and desalivated mice, the protein concentration decreased and its composition changed after major salivary gland removal. These results suggest that changes in protein concentration and composition in the saliva may be one of the factors responsible for the changes in taste preferences observed in the desalivated mice.

Indexed as

TasteTaste BudsSalivaSalivary GlandsSubmandibular GlandTaste PerceptionDesalivated miceSalivaSalivary proteinTaste preferenceTaste related molecules

Identifiers

PMID37922096
OpenAlexW4388303846

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.